Extracellular Matrix in Vascular Disease, Part 2/4: JACC Focus Seminar

Javier Barallobre-Barreiro; Bart Loeys; Manuel Mayr; Marieke Rienks; Aline Verstraeten; Jason C. Kovacic

doi:10.1016/j.jacc.2020.03.018

Extracellular Matrix in Vascular Disease, Part 2/4: JACC Focus Seminar

Javier Barallobre-Barreiro, Bart Loeys^*, Manuel Mayr, Marieke Rienks, Aline Verstraeten, Jason C. Kovacic

^*Corresponding author for this work

Vascular Biology

Research output: Contribution to journal › Review article › peer-review

63 Citations (Scopus)

Abstract

Medium-sized and large arteries consist of 3 layers: the tunica intima, tunica media, and tunica adventitia. The tunica media accounts for the bulk of the vessel wall and is the chief determinant of mechanical compliance. It is primarily composed of circumferentially arranged layers of vascular smooth muscle cells that are separated by concentrically arranged elastic lamellae; a form of extracellular matrix (ECM). The tunica media is separated from the tunica intima and tunica adventitia, the innermost and outermost layers, respectively, by the internal and external elastic laminae. This second part of a 4-part JACC Focus Seminar discusses the contributions of the ECM to vascular homeostasis and pathology. Advances in genetics and proteomics approaches have fostered significant progress in our understanding of vascular ECM. This review highlights the important role of the ECM in vascular disease and the prospect of translating these discoveries into clinical disease biomarkers and potential future therapies.

Original language	English
Pages (from-to)	2189-2203
Number of pages	15
Journal	Journal of the American College of Cardiology
Volume	75
Issue number	17
DOIs	https://doi.org/10.1016/j.jacc.2020.03.018
Publication status	Published - 5 May 2020

Keywords

aneurysm
atherosclerosis
extracellular matrix
fibromuscular dysplasia proteomics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jacc.2020.03.018

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title = "Extracellular Matrix in Vascular Disease, Part 2/4: JACC Focus Seminar",

abstract = "Medium-sized and large arteries consist of 3 layers: the tunica intima, tunica media, and tunica adventitia. The tunica media accounts for the bulk of the vessel wall and is the chief determinant of mechanical compliance. It is primarily composed of circumferentially arranged layers of vascular smooth muscle cells that are separated by concentrically arranged elastic lamellae; a form of extracellular matrix (ECM). The tunica media is separated from the tunica intima and tunica adventitia, the innermost and outermost layers, respectively, by the internal and external elastic laminae. This second part of a 4-part JACC Focus Seminar discusses the contributions of the ECM to vascular homeostasis and pathology. Advances in genetics and proteomics approaches have fostered significant progress in our understanding of vascular ECM. This review highlights the important role of the ECM in vascular disease and the prospect of translating these discoveries into clinical disease biomarkers and potential future therapies.",

keywords = "aneurysm, atherosclerosis, extracellular matrix, fibromuscular dysplasia proteomics",

author = "Javier Barallobre-Barreiro and Bart Loeys and Manuel Mayr and Marieke Rienks and Aline Verstraeten and Kovacic, {Jason C.}",

year = "2020",

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day = "5",

doi = "10.1016/j.jacc.2020.03.018",

language = "English",

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T2 - JACC Focus Seminar

AU - Barallobre-Barreiro, Javier

AU - Loeys, Bart

AU - Mayr, Manuel

AU - Rienks, Marieke

AU - Verstraeten, Aline

AU - Kovacic, Jason C.

PY - 2020/5/5

Y1 - 2020/5/5

N2 - Medium-sized and large arteries consist of 3 layers: the tunica intima, tunica media, and tunica adventitia. The tunica media accounts for the bulk of the vessel wall and is the chief determinant of mechanical compliance. It is primarily composed of circumferentially arranged layers of vascular smooth muscle cells that are separated by concentrically arranged elastic lamellae; a form of extracellular matrix (ECM). The tunica media is separated from the tunica intima and tunica adventitia, the innermost and outermost layers, respectively, by the internal and external elastic laminae. This second part of a 4-part JACC Focus Seminar discusses the contributions of the ECM to vascular homeostasis and pathology. Advances in genetics and proteomics approaches have fostered significant progress in our understanding of vascular ECM. This review highlights the important role of the ECM in vascular disease and the prospect of translating these discoveries into clinical disease biomarkers and potential future therapies.

AB - Medium-sized and large arteries consist of 3 layers: the tunica intima, tunica media, and tunica adventitia. The tunica media accounts for the bulk of the vessel wall and is the chief determinant of mechanical compliance. It is primarily composed of circumferentially arranged layers of vascular smooth muscle cells that are separated by concentrically arranged elastic lamellae; a form of extracellular matrix (ECM). The tunica media is separated from the tunica intima and tunica adventitia, the innermost and outermost layers, respectively, by the internal and external elastic laminae. This second part of a 4-part JACC Focus Seminar discusses the contributions of the ECM to vascular homeostasis and pathology. Advances in genetics and proteomics approaches have fostered significant progress in our understanding of vascular ECM. This review highlights the important role of the ECM in vascular disease and the prospect of translating these discoveries into clinical disease biomarkers and potential future therapies.

KW - aneurysm

KW - atherosclerosis

KW - extracellular matrix

KW - fibromuscular dysplasia proteomics

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DO - 10.1016/j.jacc.2020.03.018

M3 - Review article

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SN - 0735-1097

VL - 75

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EP - 2203

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 17

ER -

Extracellular Matrix in Vascular Disease, Part 2/4: JACC Focus Seminar

Abstract

Keywords

UN SDGs

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