Extracellular vesicles in COVID-19 convalescence can regulate T cell metabolism and function

Molly s. George, Jenifer Sanchez, Christina Rollings, David Fear, Peter Irving, Linda v. Sinclair, Anna Schurich

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
18 Downloads (Pure)

Abstract

Long-term T cell dysregulation has been reported following COVID-19 disease. Prolonged T cell activation is associated with disease severity and may be implicated in producing long-covid symptoms. Here, we assess the role of extracellular vesicles (EV) in regulating T cell function over several weeks post COVID-19 disease. We find that alterations in cellular origin and protein content of EV in COVID-19 convalescence are linked to initial disease severity. We demonstrate that convalescent donor-derived EV can alter the function and metabolic rewiring of CD4 and CD8 T cells. Of note, EV following mild, but not severe disease, show distinctly immune-suppressive properties, reducing T cell effector cytokine production and glucose metabolism. Mechanistically our data indicate the involvement of EV-surface ICAM-1 in facilitating EV—T cell interaction. Our data demonstrate that circulatory EV are phenotypically and functionally altered several weeks following acute infection, suggesting a role for EV as long-term immune modulators.
Original languageEnglish
Article number107280
JournaliScience
Volume26
Issue number8
Early online date3 Jul 2023
DOIs
Publication statusPublished - 18 Aug 2023

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