Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes.

Aleksandar Ivetic; Anne Ridley

doi:10.1111/j.1365-2567.2004.01882.x

Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes.

Aleksandar Ivetic, Anne Ridley

Research output: Contribution to journal › Article › peer-review

246 Citations (Scopus)

Abstract

The ezrin/radixin/moesin (ERM) family of actin-binding proteins act both as linkers between the actin cytoskeleton and plasma membrane proteins and as signal transducers in responses involving cytoskeletal remodelling. The Rho family of GTPases also regulate cytoskeletal organisation, and several molecular pathways linking ERM proteins and Rho GTPases have been described. This review discusses recent findings on ERM protein function in leucocytes and how these may be integrated with Rho GTPase signalling.

Original language	English
Pages (from-to)	165-76
Number of pages	12
Journal	Immunology
Volume	122
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2567.2004.01882.x
Publication status	Published - Jun 2004

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10.1111/j.1365-2567.2004.01882.x

Cite this

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title = "Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes.",

abstract = "The ezrin/radixin/moesin (ERM) family of actin-binding proteins act both as linkers between the actin cytoskeleton and plasma membrane proteins and as signal transducers in responses involving cytoskeletal remodelling. The Rho family of GTPases also regulate cytoskeletal organisation, and several molecular pathways linking ERM proteins and Rho GTPases have been described. This review discusses recent findings on ERM protein function in leucocytes and how these may be integrated with Rho GTPase signalling.",

author = "Aleksandar Ivetic and Anne Ridley",

year = "2004",

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AU - Ivetic, Aleksandar

AU - Ridley, Anne

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AB - The ezrin/radixin/moesin (ERM) family of actin-binding proteins act both as linkers between the actin cytoskeleton and plasma membrane proteins and as signal transducers in responses involving cytoskeletal remodelling. The Rho family of GTPases also regulate cytoskeletal organisation, and several molecular pathways linking ERM proteins and Rho GTPases have been described. This review discusses recent findings on ERM protein function in leucocytes and how these may be integrated with Rho GTPase signalling.

U2 - 10.1111/j.1365-2567.2004.01882.x

DO - 10.1111/j.1365-2567.2004.01882.x

M3 - Article

SN - 1365-2567

VL - 122

SP - 165

EP - 176

JO - Immunology

JF - Immunology

IS - 2

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