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Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes.

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)165-76
JournalImmunology
Volume122
Issue number2
Publication statusPublished - Jun 2004

King's Authors

Abstract

The ezrin/radixin/moesin (ERM) family of actin-binding proteins act both as linkers between the actin cytoskeleton and plasma membrane proteins and as signal transducers in responses involving cytoskeletal remodelling. The Rho family of GTPases also regulate cytoskeletal organisation, and several molecular pathways linking ERM proteins and Rho GTPases have been described. This review discusses recent findings on ERM protein function in leucocytes and how these may be integrated with Rho GTPase signalling.

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