F-19 NMR-STUDIES OF ENFLURANE ELIMINATION AND METABOLISM

N E  PREECE; J  CHALLANDS; S C R  WILLIAMS

doi:10.1002/nbm.1940050209

F-19 NMR-STUDIES OF ENFLURANE ELIMINATION AND METABOLISM

N E PREECE, J CHALLANDS, S C R WILLIAMS

Neuroimaging

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Abstract

The elimination and metabolism of enflurane, a fluorinated ether anaesthetic, was studied by F-19 NMR in vivo in both rat liver and brain as well as human body fluids. In the liver of thiobarbitone-anaesthetized rats the half-life for enflurane following exposure to 0. 15% (v/v) for 30 min was 76 min but this could be decreased to 39 min by pretreatment of the animals with isoniazid (0. 1% in the drinking water for 7 days), an agent known to enhance enflurane metabolism. In these animals the major organic metabolite difluoromethoxy difluoroacetate (DFMDFA) was also detected by F-19 NMR in vivo. This metabolite was detected along with fluoride ion in rat and human urine and plasma by high resolution F-19 NMR. Human urine also contained signals from a probable DFMDFA conjugate and unexpectedly from trifluoroacetate.

Original language	English
Pages (from-to)	101-106
Number of pages	6
Journal	Nmr in Biomedicine
Volume	5
Issue number	2
DOIs	https://doi.org/10.1002/nbm.1940050209
Publication status	Published - 1992

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title = "F-19 NMR-STUDIES OF ENFLURANE ELIMINATION AND METABOLISM",

abstract = "The elimination and metabolism of enflurane, a fluorinated ether anaesthetic, was studied by F-19 NMR in vivo in both rat liver and brain as well as human body fluids. In the liver of thiobarbitone-anaesthetized rats the half-life for enflurane following exposure to 0. 15% (v/v) for 30 min was 76 min but this could be decreased to 39 min by pretreatment of the animals with isoniazid (0. 1% in the drinking water for 7 days), an agent known to enhance enflurane metabolism. In these animals the major organic metabolite difluoromethoxy difluoroacetate (DFMDFA) was also detected by F-19 NMR in vivo. This metabolite was detected along with fluoride ion in rat and human urine and plasma by high resolution F-19 NMR. Human urine also contained signals from a probable DFMDFA conjugate and unexpectedly from trifluoroacetate.",

author = "PREECE, {N E} and J CHALLANDS and WILLIAMS, {S C R}",

year = "1992",

doi = "10.1002/nbm.1940050209",

language = "English",

volume = "5",

pages = "101--106",

journal = "Nmr in Biomedicine",

issn = "0952-3480",

publisher = "John Wiley and sons",

number = "2",

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TY - JOUR

T1 - F-19 NMR-STUDIES OF ENFLURANE ELIMINATION AND METABOLISM

AU - PREECE, N E

AU - CHALLANDS, J

AU - WILLIAMS, S C R

PY - 1992

Y1 - 1992

N2 - The elimination and metabolism of enflurane, a fluorinated ether anaesthetic, was studied by F-19 NMR in vivo in both rat liver and brain as well as human body fluids. In the liver of thiobarbitone-anaesthetized rats the half-life for enflurane following exposure to 0. 15% (v/v) for 30 min was 76 min but this could be decreased to 39 min by pretreatment of the animals with isoniazid (0. 1% in the drinking water for 7 days), an agent known to enhance enflurane metabolism. In these animals the major organic metabolite difluoromethoxy difluoroacetate (DFMDFA) was also detected by F-19 NMR in vivo. This metabolite was detected along with fluoride ion in rat and human urine and plasma by high resolution F-19 NMR. Human urine also contained signals from a probable DFMDFA conjugate and unexpectedly from trifluoroacetate.

AB - The elimination and metabolism of enflurane, a fluorinated ether anaesthetic, was studied by F-19 NMR in vivo in both rat liver and brain as well as human body fluids. In the liver of thiobarbitone-anaesthetized rats the half-life for enflurane following exposure to 0. 15% (v/v) for 30 min was 76 min but this could be decreased to 39 min by pretreatment of the animals with isoniazid (0. 1% in the drinking water for 7 days), an agent known to enhance enflurane metabolism. In these animals the major organic metabolite difluoromethoxy difluoroacetate (DFMDFA) was also detected by F-19 NMR in vivo. This metabolite was detected along with fluoride ion in rat and human urine and plasma by high resolution F-19 NMR. Human urine also contained signals from a probable DFMDFA conjugate and unexpectedly from trifluoroacetate.

U2 - 10.1002/nbm.1940050209

DO - 10.1002/nbm.1940050209

M3 - Article

SN - 0952-3480

VL - 5

SP - 101

EP - 106

JO - Nmr in Biomedicine

JF - Nmr in Biomedicine

IS - 2

ER -

F-19 NMR-STUDIES OF ENFLURANE ELIMINATION AND METABOLISM

Abstract

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