Fabrication of calcium phosphate microcapsules using emulsion droplets stabilized with branched copolymers as templates

Robert V. Bell; Luke A. Rochford; Rafael T. M. de Rosales; Molly Stevens; Jonathan V. M. Weaver; Stefan A. F. Bon

doi:10.1039/c5tb00893j

Fabrication of calcium phosphate microcapsules using emulsion droplets stabilized with branched copolymers as templates

Robert V. Bell, Luke A. Rochford, Rafael T. M. de Rosales, Molly Stevens, Jonathan V. M. Weaver, Stefan A. F. Bon^*

^*Corresponding author for this work

Imaging Chemistry & Biology

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

We report on a versatile and time-efficient method to fabricate calcium phosphate (CaP) microcapsules by utilizing oil-in-water emulsion droplets stabilized with synthetic branched copolymer (BCP) as templates. The BCP was designed to provide a suitable architecture and functionality to produce stable emulsion droplets, and to permit the mineralization of CaP at the surface of the oil droplet when incubated in a solution containing calcium and phosphate ions. The CaP shells of the microcapsules were established to be calcium deficient hydroxyapatite with incorporated chlorine and carbonate species. These capsule walls were made fluorescent by decoration with a fluorescein-bisphosphonate conjugate.

Original language	English
Pages (from-to)	5544-5552
Number of pages	9
Journal	Journal of materials chemistry b
Volume	3
Issue number	27
DOIs	https://doi.org/10.1039/c5tb00893j
Publication status	Published - 9 Jun 2015

Keywords

HOLLOW HYDROXYAPATITE MICROSPHERES
DRUG-DELIVERY SYSTEM
AQUEOUS-SOLUTION
HYDROTHERMAL SYNTHESIS
PROTEIN ADSORPTION
FLUORESCENT-PROBES
ROOM-TEMPERATURE
SINGLE-METAL
NANOPARTICLES
MINERALIZATION

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title = "Fabrication of calcium phosphate microcapsules using emulsion droplets stabilized with branched copolymers as templates",

abstract = "We report on a versatile and time-efficient method to fabricate calcium phosphate (CaP) microcapsules by utilizing oil-in-water emulsion droplets stabilized with synthetic branched copolymer (BCP) as templates. The BCP was designed to provide a suitable architecture and functionality to produce stable emulsion droplets, and to permit the mineralization of CaP at the surface of the oil droplet when incubated in a solution containing calcium and phosphate ions. The CaP shells of the microcapsules were established to be calcium deficient hydroxyapatite with incorporated chlorine and carbonate species. These capsule walls were made fluorescent by decoration with a fluorescein-bisphosphonate conjugate.",

keywords = "HOLLOW HYDROXYAPATITE MICROSPHERES, DRUG-DELIVERY SYSTEM, AQUEOUS-SOLUTION, HYDROTHERMAL SYNTHESIS, PROTEIN ADSORPTION, FLUORESCENT-PROBES, ROOM-TEMPERATURE, SINGLE-METAL, NANOPARTICLES, MINERALIZATION",

author = "Bell, {Robert V.} and Rochford, {Luke A.} and {de Rosales}, {Rafael T. M.} and Molly Stevens and Weaver, {Jonathan V. M.} and Bon, {Stefan A. F.}",

year = "2015",

month = jun,

day = "9",

doi = "10.1039/c5tb00893j",

language = "English",

volume = "3",

pages = "5544--5552",

journal = "Journal of materials chemistry b",

issn = "2050-750X",

publisher = "Royal Society of Chemistry",

number = "27",

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TY - JOUR

T1 - Fabrication of calcium phosphate microcapsules using emulsion droplets stabilized with branched copolymers as templates

AU - Bell, Robert V.

AU - Rochford, Luke A.

AU - de Rosales, Rafael T. M.

AU - Stevens, Molly

AU - Weaver, Jonathan V. M.

AU - Bon, Stefan A. F.

PY - 2015/6/9

Y1 - 2015/6/9

N2 - We report on a versatile and time-efficient method to fabricate calcium phosphate (CaP) microcapsules by utilizing oil-in-water emulsion droplets stabilized with synthetic branched copolymer (BCP) as templates. The BCP was designed to provide a suitable architecture and functionality to produce stable emulsion droplets, and to permit the mineralization of CaP at the surface of the oil droplet when incubated in a solution containing calcium and phosphate ions. The CaP shells of the microcapsules were established to be calcium deficient hydroxyapatite with incorporated chlorine and carbonate species. These capsule walls were made fluorescent by decoration with a fluorescein-bisphosphonate conjugate.

AB - We report on a versatile and time-efficient method to fabricate calcium phosphate (CaP) microcapsules by utilizing oil-in-water emulsion droplets stabilized with synthetic branched copolymer (BCP) as templates. The BCP was designed to provide a suitable architecture and functionality to produce stable emulsion droplets, and to permit the mineralization of CaP at the surface of the oil droplet when incubated in a solution containing calcium and phosphate ions. The CaP shells of the microcapsules were established to be calcium deficient hydroxyapatite with incorporated chlorine and carbonate species. These capsule walls were made fluorescent by decoration with a fluorescein-bisphosphonate conjugate.

KW - HOLLOW HYDROXYAPATITE MICROSPHERES

KW - DRUG-DELIVERY SYSTEM

KW - AQUEOUS-SOLUTION

KW - HYDROTHERMAL SYNTHESIS

KW - PROTEIN ADSORPTION

KW - FLUORESCENT-PROBES

KW - ROOM-TEMPERATURE

KW - SINGLE-METAL

KW - NANOPARTICLES

KW - MINERALIZATION

U2 - 10.1039/c5tb00893j

DO - 10.1039/c5tb00893j

M3 - Article

SN - 2050-750X

VL - 3

SP - 5544

EP - 5552

JO - Journal of materials chemistry b

JF - Journal of materials chemistry b

IS - 27

ER -

Fabrication of calcium phosphate microcapsules using emulsion droplets stabilized with branched copolymers as templates

Abstract

Keywords

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