Factors Affecting the Absorption, Metabolism, and Excretion of Cocoa Flavanols in Humans

Tania Cifuentes-Gomez; Ana Rodriguez-Mateos; Isidro Gonzalez-Salvador; María Elena Alañon; Jeremy P E Spencer

doi:10.1021/acs.jafc.5b00443

Factors Affecting the Absorption, Metabolism, and Excretion of Cocoa Flavanols in Humans

Tania Cifuentes-Gomez, Ana Rodriguez-Mateos, Isidro Gonzalez-Salvador, María Elena Alañon, Jeremy P E Spencer

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Cocoa is rich in a subclass of flavonoids known as flavanols, the cardiovascular health benefits of which have been extensively reported. The appearance of flavanol metabolites in the systemic circulation after flavanol-rich food consumption is likely to mediate the physiological effects on the vascular system, and these levels are influenced by numerous factors, including food matrix, processing, intake, age, gender, or genetic polymorphisms, among others. This review will focus on our current understanding of factors affecting the absorption, metabolism, and excretion of cocoa flavanols in humans. Second, it will identify gaps in these contributing factors that need to be addressed to conclusively translate our collective knowledge into the context of public health, dietary guidelines, and evidence-based dietary recommendations.

Original language	English
Pages (from-to)	7615-23
Number of pages	9
Journal	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume	63
Issue number	35
DOIs	https://doi.org/10.1021/acs.jafc.5b00443
Publication status	Published - 9 Sept 2015

Keywords

Cacao
Digestion
Female
Flavonoids
Gastrointestinal Absorption
Humans
Male

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acs.jafc.5b00443

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abstract = "Cocoa is rich in a subclass of flavonoids known as flavanols, the cardiovascular health benefits of which have been extensively reported. The appearance of flavanol metabolites in the systemic circulation after flavanol-rich food consumption is likely to mediate the physiological effects on the vascular system, and these levels are influenced by numerous factors, including food matrix, processing, intake, age, gender, or genetic polymorphisms, among others. This review will focus on our current understanding of factors affecting the absorption, metabolism, and excretion of cocoa flavanols in humans. Second, it will identify gaps in these contributing factors that need to be addressed to conclusively translate our collective knowledge into the context of public health, dietary guidelines, and evidence-based dietary recommendations.",

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AU - Cifuentes-Gomez, Tania

AU - Rodriguez-Mateos, Ana

AU - Gonzalez-Salvador, Isidro

AU - Alañon, María Elena

AU - Spencer, Jeremy P E

PY - 2015/9/9

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N2 - Cocoa is rich in a subclass of flavonoids known as flavanols, the cardiovascular health benefits of which have been extensively reported. The appearance of flavanol metabolites in the systemic circulation after flavanol-rich food consumption is likely to mediate the physiological effects on the vascular system, and these levels are influenced by numerous factors, including food matrix, processing, intake, age, gender, or genetic polymorphisms, among others. This review will focus on our current understanding of factors affecting the absorption, metabolism, and excretion of cocoa flavanols in humans. Second, it will identify gaps in these contributing factors that need to be addressed to conclusively translate our collective knowledge into the context of public health, dietary guidelines, and evidence-based dietary recommendations.

AB - Cocoa is rich in a subclass of flavonoids known as flavanols, the cardiovascular health benefits of which have been extensively reported. The appearance of flavanol metabolites in the systemic circulation after flavanol-rich food consumption is likely to mediate the physiological effects on the vascular system, and these levels are influenced by numerous factors, including food matrix, processing, intake, age, gender, or genetic polymorphisms, among others. This review will focus on our current understanding of factors affecting the absorption, metabolism, and excretion of cocoa flavanols in humans. Second, it will identify gaps in these contributing factors that need to be addressed to conclusively translate our collective knowledge into the context of public health, dietary guidelines, and evidence-based dietary recommendations.

KW - Cacao

KW - Digestion

KW - Female

KW - Flavonoids

KW - Gastrointestinal Absorption

KW - Humans

KW - Male

U2 - 10.1021/acs.jafc.5b00443

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M3 - Article

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ER -

Factors Affecting the Absorption, Metabolism, and Excretion of Cocoa Flavanols in Humans

Abstract

Keywords

UN SDGs

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