Factors associated with single versus multiple suicide attempts in depressive disorders

Leonardo Tondo; Ross J Baldessarini; Margherita Barbuti; Paola Colombini; Jules Angst; Jean-Michel Azorin; Charles L Bowden; Sergey Mosolov; Allan H Young; Eduard Vieta; Giulio Perugi

doi:10.1016/j.jad.2020.08.021

Factors associated with single versus multiple suicide attempts in depressive disorders

Leonardo Tondo, Ross J Baldessarini, Margherita Barbuti, Paola Colombini, Jules Angst, Jean-Michel Azorin, Charles L Bowden, Sergey Mosolov, Allan H Young, Eduard Vieta, Giulio Perugi

International Consortium for Research on Mood and Psychotic Disorders, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Lucio Bini Mood Disorders Centers, Cagliari, Rome, Italy.
International Consortium for Research on Mood and Psychotic Disorders, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Department of Experimental and Clinical Medicine, Section of Psychiatry, University of Pisa, Via Savi 10, 56126 Pisa, Italy.
University Hospital of Zurich
Department of Psychiatry, Hôpital Sainte Marguerite, University Hospitals of Marseille, Marseille, France.
University of Texas Health Science Center at San Antonio
Moscow Research Institute of Psychiatry
Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London & South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Monks Orchard Road, Beckenham, Kent, BR3 3BX, United Kingdom.
Bipolar and Depressive Disorders Unit, Department of Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic de Barcelona, University of Barcelona, IDIBAPS, CIBERSAM, Villaroel 170, 08036, Barcelona, Catalonia, Spain.
Department of Experimental and Clinical Medicine, Section of Psychiatry, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address: [email protected].

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

86 Downloads (Pure)

Abstract

BACKGROUND: Many risk factors for suicidal behavior have been identified. Much less has been done to associate risk factors with recurrence of suicidal behavior.

METHODS: We compared prevalence of 30 potential risk factors among 8496 depressive patient-subjects from the BRIDGE consortium with no (NSA, n = 6267), one (1SA, n = 1123), or repeated (≥2) suicide attempts (RSA, n = 1106).

RESULTS: Prevalence of most factors ranked: RSA ≥ 1SA > NSA, with a notable opposite trend for the diagnosis of type II bipolar disorder (BD). Factors independently and significantly more present among RSA than 1SA subjects were: borderline personality, substance abuse, mood-switching with antidepressant treatment, female sex, and unsatisfactory response to antidepressant treatment. There also were notably strong associations of RSA with type I or probable BD and associated factors, including family history of BD, young onset, mixed and psychotic features.

LIMITATIONS: Potential effects of treatment on risk of suicidal acts could not be evaluated adequately, as well as associations between levels of suicidal behavior and eventual death by suicide.

CONCLUSIONS: In a large cohort of depressive patients, there were significant associations not only with suicidal behavior generally, but also with the intensity of suicide attempts.

Original language	English
Pages (from-to)	306-312
Number of pages	7
Journal	Journal of Affective Disorders
Volume	277
Early online date	14 Aug 2020
DOIs	https://doi.org/10.1016/j.jad.2020.08.021
Publication status	Published - 1 Dec 2020

Keywords

Bipolar disorder
Depressive episode
Suicide attempts

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Factors associated with single versus multiple suicide attempts in depressive disorders",

abstract = "BACKGROUND: Many risk factors for suicidal behavior have been identified. Much less has been done to associate risk factors with recurrence of suicidal behavior.METHODS: We compared prevalence of 30 potential risk factors among 8496 depressive patient-subjects from the BRIDGE consortium with no (NSA, n = 6267), one (1SA, n = 1123), or repeated (≥2) suicide attempts (RSA, n = 1106).RESULTS: Prevalence of most factors ranked: RSA ≥ 1SA > NSA, with a notable opposite trend for the diagnosis of type II bipolar disorder (BD). Factors independently and significantly more present among RSA than 1SA subjects were: borderline personality, substance abuse, mood-switching with antidepressant treatment, female sex, and unsatisfactory response to antidepressant treatment. There also were notably strong associations of RSA with type I or probable BD and associated factors, including family history of BD, young onset, mixed and psychotic features.LIMITATIONS: Potential effects of treatment on risk of suicidal acts could not be evaluated adequately, as well as associations between levels of suicidal behavior and eventual death by suicide.CONCLUSIONS: In a large cohort of depressive patients, there were significant associations not only with suicidal behavior generally, but also with the intensity of suicide attempts.",

keywords = "Bipolar disorder, Depressive episode, Suicide attempts",

author = "Leonardo Tondo and Baldessarini, {Ross J} and Margherita Barbuti and Paola Colombini and Jules Angst and Jean-Michel Azorin and Bowden, {Charles L} and Sergey Mosolov and Young, {Allan H} and Eduard Vieta and Giulio Perugi",

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AU - Tondo, Leonardo

AU - Baldessarini, Ross J

AU - Barbuti, Margherita

AU - Colombini, Paola

AU - Angst, Jules

AU - Azorin, Jean-Michel

AU - Bowden, Charles L

AU - Mosolov, Sergey

AU - Young, Allan H

AU - Vieta, Eduard

AU - Perugi, Giulio

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N2 - BACKGROUND: Many risk factors for suicidal behavior have been identified. Much less has been done to associate risk factors with recurrence of suicidal behavior.METHODS: We compared prevalence of 30 potential risk factors among 8496 depressive patient-subjects from the BRIDGE consortium with no (NSA, n = 6267), one (1SA, n = 1123), or repeated (≥2) suicide attempts (RSA, n = 1106).RESULTS: Prevalence of most factors ranked: RSA ≥ 1SA > NSA, with a notable opposite trend for the diagnosis of type II bipolar disorder (BD). Factors independently and significantly more present among RSA than 1SA subjects were: borderline personality, substance abuse, mood-switching with antidepressant treatment, female sex, and unsatisfactory response to antidepressant treatment. There also were notably strong associations of RSA with type I or probable BD and associated factors, including family history of BD, young onset, mixed and psychotic features.LIMITATIONS: Potential effects of treatment on risk of suicidal acts could not be evaluated adequately, as well as associations between levels of suicidal behavior and eventual death by suicide.CONCLUSIONS: In a large cohort of depressive patients, there were significant associations not only with suicidal behavior generally, but also with the intensity of suicide attempts.

AB - BACKGROUND: Many risk factors for suicidal behavior have been identified. Much less has been done to associate risk factors with recurrence of suicidal behavior.METHODS: We compared prevalence of 30 potential risk factors among 8496 depressive patient-subjects from the BRIDGE consortium with no (NSA, n = 6267), one (1SA, n = 1123), or repeated (≥2) suicide attempts (RSA, n = 1106).RESULTS: Prevalence of most factors ranked: RSA ≥ 1SA > NSA, with a notable opposite trend for the diagnosis of type II bipolar disorder (BD). Factors independently and significantly more present among RSA than 1SA subjects were: borderline personality, substance abuse, mood-switching with antidepressant treatment, female sex, and unsatisfactory response to antidepressant treatment. There also were notably strong associations of RSA with type I or probable BD and associated factors, including family history of BD, young onset, mixed and psychotic features.LIMITATIONS: Potential effects of treatment on risk of suicidal acts could not be evaluated adequately, as well as associations between levels of suicidal behavior and eventual death by suicide.CONCLUSIONS: In a large cohort of depressive patients, there were significant associations not only with suicidal behavior generally, but also with the intensity of suicide attempts.

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KW - Depressive episode

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Factors associated with single versus multiple suicide attempts in depressive disorders

Abstract

Keywords

UN SDGs

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