Factors influencing depression endpoints research (FINDER): Study design and population characteristics

A Garcia-Cebrian, M Bauer, A L Montejo, N Dantchev, K Demyttenaere, P Gandhi, L Grassi, B U Monz, D G S Perahia, D Quail, A Tylee

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Factors influencing outcomes of depression in clinical practice, especially health-related quality of life (HRQoL), are poorly understood. The Factors Influencing Depression Endpoints Research (FINDER) study is a European prospective, observational study designed to estimate the HRQoL of adults with a clinically diagnosed depressive episode at baseline, and 3 and 6 months after commencing antidepressant medication. We report here the study design and baseline patient characteristics. HRQoL was assessed by the 36-item Short-Form Health Survey (SF-36) and European Quality of Life-5 Dimensions (EQ-5D). Patient ratings on Hospital Anxiety and Depression Scale (HADS) and pain Visual Analogue Scale (VAS) were also obtained. Results (n = 3468) showed that SF-36 mental component summary (mean 22.2) was more than two SDs below general population norms (mean 50.0) and one SD below clinical depression norms (mean 34.8); the physical component summary (mean 46.1) was similar to general population (mean 50.0) and clinical depression norms (mean 45.0). Mean EQ-5D scores were also lower than general population norms. Mean HADS-Depression and -Anxiety sub-scores were 12.3 and 13.0, respectively. Fifty-six percent of patients reported an overall pain VAS score of at least 30 mm and 70% of these patients had no physical explanation for their pain. Further investigation into factors associated with HRQoL in depression after treatment initiation is warranted. (C) 2007 Elsevier Masson SAS. All rights reserved
Original languageEnglish
Pages (from-to)57 - 65
Number of pages9
JournalEuropean Psychiatry
Issue number1
Publication statusPublished - Jan 2008


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