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Factors influencing recruitment to a randomised placebo-controlled trial of oral naltrexone and extended release implant naltrexone: qualitative study

Research output: Contribution to journalArticle

Standard

Factors influencing recruitment to a randomised placebo-controlled trial of oral naltrexone and extended release implant naltrexone : qualitative study. / Tompkins, Charlotte N. E.; Neale, Joanne; Marsden, John; Strang, John S.

In: Journal of Substance Abuse Treatment, Vol. 99, 04.2019, p. 52-60.

Research output: Contribution to journalArticle

Harvard

Tompkins, CNE, Neale, J, Marsden, J & Strang, JS 2019, 'Factors influencing recruitment to a randomised placebo-controlled trial of oral naltrexone and extended release implant naltrexone: qualitative study', Journal of Substance Abuse Treatment, vol. 99, pp. 52-60. https://doi.org/10.1016/j.jsat.2019.01.012

APA

Tompkins, C. N. E., Neale, J., Marsden, J., & Strang, J. S. (2019). Factors influencing recruitment to a randomised placebo-controlled trial of oral naltrexone and extended release implant naltrexone: qualitative study. Journal of Substance Abuse Treatment, 99, 52-60. https://doi.org/10.1016/j.jsat.2019.01.012

Vancouver

Tompkins CNE, Neale J, Marsden J, Strang JS. Factors influencing recruitment to a randomised placebo-controlled trial of oral naltrexone and extended release implant naltrexone: qualitative study. Journal of Substance Abuse Treatment. 2019 Apr;99:52-60. https://doi.org/10.1016/j.jsat.2019.01.012

Author

Tompkins, Charlotte N. E. ; Neale, Joanne ; Marsden, John ; Strang, John S. / Factors influencing recruitment to a randomised placebo-controlled trial of oral naltrexone and extended release implant naltrexone : qualitative study. In: Journal of Substance Abuse Treatment. 2019 ; Vol. 99. pp. 52-60.

Bibtex Download

@article{843ca033d6a44a23b4c64a40e3362336,
title = "Factors influencing recruitment to a randomised placebo-controlled trial of oral naltrexone and extended release implant naltrexone: qualitative study",
abstract = "AimsTo understand the influences on recruitment to the Naltrexone Enhanced Addiction Treatment (NEAT) study, a randomised placebo-controlled trial of extended-release naltrexone (XR-NTX) implants for opioid use disorder (OUD), to learn lessons for the design and conduct of similar future research.Methods29 face-to-face, semi-structured qualitative interviews were conducted with patients recruited to NEAT (n = 6), patients not recruited (n = 11), researchers who designed the trial (n = 5), and staff who delivered the trial (n = 7). The social marketing mix was used as a framework to guide the data analyses.ResultsDimensions of the 7Ps of the social marketing mix - product, price, place, promotion, physical environment, people, and processes all influenced recruitment to the NEAT trial. Among other things, the potential to receive a naltrexone implant (product); the provision of transport passes and shopping vouchers (price); clear verbal explanations (promotion); familiarity of the trial setting (physical environment); and approachable, friendly and informative trial delivery staff (people) positively influenced recruitment. Whereas, wanting a less medical approach to recovery (product); the perceived time, physical, and psychological costs of taking part (price); service ideological opposition to naltrexone in recovery (place); inaccessible written information (promotion); the location and nature of the trial setting (physical environment); a lack of knowledge about implants (people); and the blind allocation and potential of placebo (processes) deterred people from joining the trial.ConclusionsQualitative research informed by the social marketing mix as an analytical framework yielded detailed insights into understanding the factors and circumstances that influenced recruitment to the NEAT trial. Our findings have implications for the planning and implementation of future addiction trials, especially trials of extended-release formulations.",
author = "Tompkins, {Charlotte N. E.} and Joanne Neale and John Marsden and Strang, {John S}",
year = "2019",
month = "4",
doi = "10.1016/j.jsat.2019.01.012",
language = "English",
volume = "99",
pages = "52--60",
journal = "Journal of Substance Abuse Treatment",
issn = "0740-5472",
publisher = "Elsevier Inc.",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Factors influencing recruitment to a randomised placebo-controlled trial of oral naltrexone and extended release implant naltrexone

T2 - qualitative study

AU - Tompkins, Charlotte N. E.

AU - Neale, Joanne

AU - Marsden, John

AU - Strang, John S

PY - 2019/4

Y1 - 2019/4

N2 - AimsTo understand the influences on recruitment to the Naltrexone Enhanced Addiction Treatment (NEAT) study, a randomised placebo-controlled trial of extended-release naltrexone (XR-NTX) implants for opioid use disorder (OUD), to learn lessons for the design and conduct of similar future research.Methods29 face-to-face, semi-structured qualitative interviews were conducted with patients recruited to NEAT (n = 6), patients not recruited (n = 11), researchers who designed the trial (n = 5), and staff who delivered the trial (n = 7). The social marketing mix was used as a framework to guide the data analyses.ResultsDimensions of the 7Ps of the social marketing mix - product, price, place, promotion, physical environment, people, and processes all influenced recruitment to the NEAT trial. Among other things, the potential to receive a naltrexone implant (product); the provision of transport passes and shopping vouchers (price); clear verbal explanations (promotion); familiarity of the trial setting (physical environment); and approachable, friendly and informative trial delivery staff (people) positively influenced recruitment. Whereas, wanting a less medical approach to recovery (product); the perceived time, physical, and psychological costs of taking part (price); service ideological opposition to naltrexone in recovery (place); inaccessible written information (promotion); the location and nature of the trial setting (physical environment); a lack of knowledge about implants (people); and the blind allocation and potential of placebo (processes) deterred people from joining the trial.ConclusionsQualitative research informed by the social marketing mix as an analytical framework yielded detailed insights into understanding the factors and circumstances that influenced recruitment to the NEAT trial. Our findings have implications for the planning and implementation of future addiction trials, especially trials of extended-release formulations.

AB - AimsTo understand the influences on recruitment to the Naltrexone Enhanced Addiction Treatment (NEAT) study, a randomised placebo-controlled trial of extended-release naltrexone (XR-NTX) implants for opioid use disorder (OUD), to learn lessons for the design and conduct of similar future research.Methods29 face-to-face, semi-structured qualitative interviews were conducted with patients recruited to NEAT (n = 6), patients not recruited (n = 11), researchers who designed the trial (n = 5), and staff who delivered the trial (n = 7). The social marketing mix was used as a framework to guide the data analyses.ResultsDimensions of the 7Ps of the social marketing mix - product, price, place, promotion, physical environment, people, and processes all influenced recruitment to the NEAT trial. Among other things, the potential to receive a naltrexone implant (product); the provision of transport passes and shopping vouchers (price); clear verbal explanations (promotion); familiarity of the trial setting (physical environment); and approachable, friendly and informative trial delivery staff (people) positively influenced recruitment. Whereas, wanting a less medical approach to recovery (product); the perceived time, physical, and psychological costs of taking part (price); service ideological opposition to naltrexone in recovery (place); inaccessible written information (promotion); the location and nature of the trial setting (physical environment); a lack of knowledge about implants (people); and the blind allocation and potential of placebo (processes) deterred people from joining the trial.ConclusionsQualitative research informed by the social marketing mix as an analytical framework yielded detailed insights into understanding the factors and circumstances that influenced recruitment to the NEAT trial. Our findings have implications for the planning and implementation of future addiction trials, especially trials of extended-release formulations.

UR - http://www.scopus.com/inward/record.url?scp=85060098020&partnerID=8YFLogxK

U2 - 10.1016/j.jsat.2019.01.012

DO - 10.1016/j.jsat.2019.01.012

M3 - Article

VL - 99

SP - 52

EP - 60

JO - Journal of Substance Abuse Treatment

JF - Journal of Substance Abuse Treatment

SN - 0740-5472

ER -

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