King's College London

TY - JOUR

T1 - Factors influencing the choice of monoclonal antibodies for antibody–drug conjugates

AU - Hasan, Mahbub

AU - Jin, Peiqin

AU - Laws, Mark

AU - Rahman, Miraz

N1 - Funding Information: The authors would like to thank the Commonwealth Scholarship Commission in the UK for supporting M.M.H. during his PhD studies. Publisher Copyright: © 2021 Elsevier Ltd Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2022/1

Y1 - 2022/1

N2 - In antibody–drug conjugates (ADCs), monoclonal antibodies (mAbs) act as carriers for a cytotoxic payload providing the therapy with targeted action against cells expressing a target cell surface antigen. An appropriate choice of mAb is crucial to developing a successful ADC for clinical development. However, problems such as immunogenicity, poor pharmacokinetic (PK) and pharmacodynamic(PD) profiles and variable drug–antibody ratios (DARs) plague ADCs. In this review, we detail recent mAb-based innovations and factors that should be considered to overcome these problems to achieve a new generation of more effective ADC therapeutics.

AB - In antibody–drug conjugates (ADCs), monoclonal antibodies (mAbs) act as carriers for a cytotoxic payload providing the therapy with targeted action against cells expressing a target cell surface antigen. An appropriate choice of mAb is crucial to developing a successful ADC for clinical development. However, problems such as immunogenicity, poor pharmacokinetic (PK) and pharmacodynamic(PD) profiles and variable drug–antibody ratios (DARs) plague ADCs. In this review, we detail recent mAb-based innovations and factors that should be considered to overcome these problems to achieve a new generation of more effective ADC therapeutics.

UR - http://www.scopus.com/inward/record.url?scp=85116890308&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.drudis.2021.09.015

DO - https://doi.org/10.1016/j.drudis.2021.09.015

M3 - Review article

VL - 27

SP - 354

EP - 361

JO - DRUG DISCOVERY TODAY

JF - DRUG DISCOVERY TODAY

SN - 1359-6446

IS - 1

ER -