Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples

TY - JOUR

T1 - Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples

AU - Xu, X H

AU - Mill, J

AU - Zhou, K X

AU - Brookes, K

AU - Chen, C K

AU - Asherson, P

PY - 2007/1/5

Y1 - 2007/1/5

N2 - Brain-derived neurotrophic factor (BDNF) plays an important role in normal neuronal development. Several lines of evidence implicate the involvement of BDNF in attention-deficit hyperactivity disorder (ADHD). This study investigated the role of two common BDNF variants (Va166Met, C270T) in two samples of ADHD probands from the United Kingdom (n=180) and Taiwan (n=212). We found evidence of increased transmission of the C allele of the C270T in Taiwanese samples (TDT: chi(2) = 6.78, P = 0.009) and the two samples pooled together (TDT: chi(2) = 7.24, P = 0.007). No association was found between the Va166Met polymorphism and ADHD in either of the two populations. Analysis of haplotypes demonstrated a significant decreased transmission of haplotypes containing the Va166 allele and the 270T allele in the Taiwanese samples (TDT: chi(2) = 4.57, P = 0.032) and the pooled sample set (TDT: chi(2) = 5.82, P=0.016). This study provides evidence for the possible involvement of BDNF in susceptibility to ADHD. (c) 2006 Wiley-Liss, Inc

AB - Brain-derived neurotrophic factor (BDNF) plays an important role in normal neuronal development. Several lines of evidence implicate the involvement of BDNF in attention-deficit hyperactivity disorder (ADHD). This study investigated the role of two common BDNF variants (Va166Met, C270T) in two samples of ADHD probands from the United Kingdom (n=180) and Taiwan (n=212). We found evidence of increased transmission of the C allele of the C270T in Taiwanese samples (TDT: chi(2) = 6.78, P = 0.009) and the two samples pooled together (TDT: chi(2) = 7.24, P = 0.007). No association was found between the Va166Met polymorphism and ADHD in either of the two populations. Analysis of haplotypes demonstrated a significant decreased transmission of haplotypes containing the Va166 allele and the 270T allele in the Taiwanese samples (TDT: chi(2) = 4.57, P = 0.032) and the pooled sample set (TDT: chi(2) = 5.82, P=0.016). This study provides evidence for the possible involvement of BDNF in susceptibility to ADHD. (c) 2006 Wiley-Liss, Inc

U2 - 10.1002/ajmg.b.30406

DO - 10.1002/ajmg.b.30406

M3 - Article

SN - 1552-485X

VL - 144B

SP - 83

EP - 86

JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

IS - 1

ER -