Fast myocardial T₁ mapping using shortened inversion recovery based schemes

TY - JOUR

T1 - Fast myocardial T1 mapping using shortened inversion recovery based schemes

AU - Huang, Li

AU - Neji, Radhouene

AU - Nazir, Muhummad Sohaib

AU - Whitaker, John

AU - Reid, Fiona

AU - Bosio, Filippo

AU - Chiribiri, Amedeo

AU - Razavi, Reza

AU - Roujol, Sébastien

PY - 2019/8/1

Y1 - 2019/8/1

N2 - BACKGROUND: Myocardial T1 mapping shows promise for assessment of cardiomyopathies. Most myocardial T1 mapping techniques, such as modified Look-Locker inversion recovery (MOLLI), generate one T1 map per breath-held acquisition (9-17 heartbeats), which prolongs multislice protocols and may be unsuitable for patients with breath-holding difficulties. PURPOSE: To develop and characterize novel shortened inversion recovery based T1 mapping schemes of 2-5 heartbeats. STUDY TYPE: Prospective. POPULATION/PHANTOM: Numerical simulations, agarose/NiCl2 phantom, 16 healthy volunteers, and 24 patients. FIELD STRENGTH/SEQUENCE: 1.5T/MOLLI. ASSESSMENT: All shortened T1 mapping schemes were characterized and compared with a conventional MOLLI scheme (5-(3)-3) in terms of accuracy, precision, spatial variability, and repeatability. STATISTICAL TESTS: Kruskal-Wallis, Wilcoxon rank sum tests, analysis of variance, Student's t-tests, Bland-Altman analysis, and Pearson correlation analysis. RESULTS: All shortened schemes provided limited T1 time variations ( 0.71). In healthy volunteers, there were no statistically significant differences between all schemes in terms of native T1 times and repeatability for myocardium (P = 0.21 and P = 0.87, respectively) and blood (P = 0.79 and P = 0.41, respectively). All shortened schemes led to a limited increase of spatial variability for native myocardial T1 mapping with respect to MOLLI (by a factor of 1.2) (P <0.0001). In both healthy volunteers and patients, the two-heartbeat scheme and MOLLI led to highly linearly correlated T1 times (correlation coefficients >/=0.83). DATA CONCLUSION: The proposed two-heartbeat T1 mapping scheme yields a 5-fold acceleration compared with MOLLI, with highly linearly correlated T1 times, no significant difference of repeatability, and limited spatial variability penalty at 1.5T. This approach may enable myocardial T1 mapping in patients with severe breath-holding difficulties and reduce the examination time of multislice protocols. LEVEL OF EVIDENCE: 1 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2019.

AB - BACKGROUND: Myocardial T1 mapping shows promise for assessment of cardiomyopathies. Most myocardial T1 mapping techniques, such as modified Look-Locker inversion recovery (MOLLI), generate one T1 map per breath-held acquisition (9-17 heartbeats), which prolongs multislice protocols and may be unsuitable for patients with breath-holding difficulties. PURPOSE: To develop and characterize novel shortened inversion recovery based T1 mapping schemes of 2-5 heartbeats. STUDY TYPE: Prospective. POPULATION/PHANTOM: Numerical simulations, agarose/NiCl2 phantom, 16 healthy volunteers, and 24 patients. FIELD STRENGTH/SEQUENCE: 1.5T/MOLLI. ASSESSMENT: All shortened T1 mapping schemes were characterized and compared with a conventional MOLLI scheme (5-(3)-3) in terms of accuracy, precision, spatial variability, and repeatability. STATISTICAL TESTS: Kruskal-Wallis, Wilcoxon rank sum tests, analysis of variance, Student's t-tests, Bland-Altman analysis, and Pearson correlation analysis. RESULTS: All shortened schemes provided limited T1 time variations ( 0.71). In healthy volunteers, there were no statistically significant differences between all schemes in terms of native T1 times and repeatability for myocardium (P = 0.21 and P = 0.87, respectively) and blood (P = 0.79 and P = 0.41, respectively). All shortened schemes led to a limited increase of spatial variability for native myocardial T1 mapping with respect to MOLLI (by a factor of 1.2) (P <0.0001). In both healthy volunteers and patients, the two-heartbeat scheme and MOLLI led to highly linearly correlated T1 times (correlation coefficients >/=0.83). DATA CONCLUSION: The proposed two-heartbeat T1 mapping scheme yields a 5-fold acceleration compared with MOLLI, with highly linearly correlated T1 times, no significant difference of repeatability, and limited spatial variability penalty at 1.5T. This approach may enable myocardial T1 mapping in patients with severe breath-holding difficulties and reduce the examination time of multislice protocols. LEVEL OF EVIDENCE: 1 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2019.

KW - Look-Locker

KW - MOLLI

KW - T mapping

KW - inversion recovery

KW - myocardial tissue characterization

KW - T 1 mapping

UR - http://www.scopus.com/inward/record.url?scp=85060533222&partnerID=8YFLogxK

U2 - 10.1002/jmri.26649

DO - 10.1002/jmri.26649

M3 - Article

SN - 1522-2586

VL - 50

SP - 641

EP - 654

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

IS - 2

ER -