FASt single-breathhold 2D multislice myocardial T1 mapping (FAST1) at 1.5T for full left ventricular coverage in three breathholds

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Background: Conventional myocardial T 1 mapping techniques such as modified Look–Locker inversion recovery (MOLLI) generate one T 1 map per breathhold. T 1 mapping with full left ventricular coverage may be desirable when spatial T 1 variations are expected. This would require multiple breathholds, increasing patient discomfort and prolonging scan time. Purpose: To develop and characterize a novel FASt single-breathhold 2D multislice myocardial T 1 mapping (FAST1) technique for full left ventricular coverage. Study Type: Prospective. Population/Phantom: Numerical simulation, agarose/NiCl 2 phantom, 9 healthy volunteers, and 17 patients. Field Strength/Sequence: 1.5T/FAST1. Assessment: Two FAST1 approaches, FAST1-BS and FAST1-IR, were characterized and compared with standard 5-(3)-3 MOLLI in terms of accuracy, precision/spatial variability, and repeatability. Statistical Tests: Kruskal-Wallis, Wilcoxon signed rank tests, intraclass correlation coefficient analysis, analysis of variance, Student's t-tests, Pearson correlation analysis, and Bland–Altman analysis. Results: In simulation/phantom, FAST1-BS, FAST1-IR, and MOLLI had an accuracy (expressed as T 1 error) of 0.2%/4%, 6%/9%, and 4%/7%, respectively, while FAST1-BS and FAST1-IR had a precision penalty of 1.7/1.5 and 1.5/1.4 in comparison with MOLLI, respectively. In healthy volunteers, FAST1-BS/FAST1-IR/MOLLI led to different native myocardial T 1 times (1016 ± 27 msec/952 ±22 msec/987 ± 23 msec, P < 0.0001) and spatial variability (66 ± 10 msec/57 ± 8 msec/46 ± 7 msec, P < 0.001). There were no statistically significant differences between all techniques for T 1 repeatability (P = 0.18). In vivo native and postcontrast myocardial T 1 times in both healthy volunteers and patients using FAST1-BS/FAST1-IR were highly correlated with MOLLI (Pearson correlation coefficient ≥0.93). Data Conclusion: FAST1 enables myocardial T 1 mapping with full left ventricular coverage in three separated breathholds. In comparison with MOLLI, FAST1 yield a 5-fold increase of spatial coverage, limited penalty of T 1 precision/spatial variability, no significant difference of T 1 repeatability, and highly correlated T 1 times. FAST1-IR provides improved T 1 precision/spatial variability but reduced accuracy when compared with FAST1-BS. Level of Evidence: 1. Technical Efficacy: Stage 3. J. Magn. Reson. Imaging 2020;51:492–504.

Original languageEnglish
Pages (from-to)492-504
Number of pages13
JournalJournal of Magnetic Resonance Imaging
Issue number2
Early online date24 Jul 2019
Publication statusPublished - 1 Feb 2020


  • T1 mapping
  • inversion recovery
  • multislice
  • myocardial tissue characterization
  • slice-selective


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