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Fetal fibronectin as a predictor of spontaneous preterm labour in asymptomatic women with a cervical cerclage

Research output: Contribution to journalArticle

K. E. Duhig, M. Chandiramani, P. T. Seed, A. L. Briley, A. P. Kenyon, A. H. Shennan

Original languageEnglish
Pages (from-to)799 - 803
Number of pages5
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume116
Issue number6
Early online date23 Apr 2009
DOIs
Publication statusPublished - May 2009

King's Authors

Abstract

To assess the accuracy of fetal fibronectin (fFN) testing for prediction of preterm labour in asymptomatic high-risk women with a cervical cerclage. Retrospective observational study. United Kingdom. Nine hundred and ten asymptomatic women at high-risk of Preterm birth referred to specialist antenatal clinics and undergoing fFN testing between November 1997 and December 2007. Women had fFN tests taken between 23(+0) and 27(+6) weeks' gestation, on one or more occasions. Sensitivity, specificity, positive predictive values and negative predictive values of fFN testing for predicting delivery <30 and <37 weeks were compared in those with and without cerclage. For delivery <30 weeks' gestation, the specificity of fFN testing was significantly lower in women with cervical cerclage (77% vs 90%; P 0.4). The negative predictive value of the fFN test for delivery <30 weeks was high in both groups (> 98%). Asymptomatic high-risk women with cerclage in situ are more likely to have a false positive fFN test. The negative predictive value is similar.

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