FGF21 regulates sweet and alcohol preference

Saswata Talukdar; Bryn M. Owen; Parkyong Song; Genaro Hernandez; Yuan Zhang; Yingjiang Zhou; William T. Scott; Bhavna Paratala; Tod Turner; Andrew Smith; Barbara Bernardo; Christian P. Müller; Hao Tang; David J. Mangelsdorf; Bryan Goodwin; Steven A. Kliewer

doi:10.1016/j.cmet.2015.12.008

FGF21 regulates sweet and alcohol preference

Saswata Talukdar, Bryn M. Owen, Parkyong Song, Genaro Hernandez, Yuan Zhang, Yingjiang Zhou, William T. Scott, Bhavna Paratala, Tod Turner, Andrew Smith, Barbara Bernardo, Christian P. Müller, Hao Tang, David J. Mangelsdorf^*, Bryan Goodwin, Steven A. Kliewer

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

249 Citations (Scopus)

Abstract

Fibroblast growth factor 21 (FGF21) is a hormone induced by various metabolic stresses, including ketogenic and high-carbohydrate diets, that regulates energy homeostasis. In humans, SNPs in and around the FGF21 gene have been associated with macronutrient preference, including carbohydrate, fat, and protein intake. Here we show that FGF21 administration markedly reduces sweet and alcohol preference in mice and sweet preference in cynomolgus monkeys. In mice, these effects require the FGF21 co-receptor β-Klotho in the central nervous system and correlate with reductions in dopamine concentrations in the nucleus accumbens. Since analogs of FGF21 are currently undergoing clinical evaluation for the treatment of obesity and type 2 diabetes, our findings raise the possibility that FGF21 administration could affect nutrient preference and other reward behaviors in humans.

Original language	English
Pages (from-to)	344-349
Number of pages	6
Journal	CELL METABOLISM
Volume	23
Issue number	2
Early online date	24 Dec 2015
DOIs	https://doi.org/10.1016/j.cmet.2015.12.008
Publication status	Published - 9 Feb 2016

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title = "FGF21 regulates sweet and alcohol preference",

abstract = "Fibroblast growth factor 21 (FGF21) is a hormone induced by various metabolic stresses, including ketogenic and high-carbohydrate diets, that regulates energy homeostasis. In humans, SNPs in and around the FGF21 gene have been associated with macronutrient preference, including carbohydrate, fat, and protein intake. Here we show that FGF21 administration markedly reduces sweet and alcohol preference in mice and sweet preference in cynomolgus monkeys. In mice, these effects require the FGF21 co-receptor β-Klotho in the central nervous system and correlate with reductions in dopamine concentrations in the nucleus accumbens. Since analogs of FGF21 are currently undergoing clinical evaluation for the treatment of obesity and type 2 diabetes, our findings raise the possibility that FGF21 administration could affect nutrient preference and other reward behaviors in humans.",

author = "Saswata Talukdar and Owen, {Bryn M.} and Parkyong Song and Genaro Hernandez and Yuan Zhang and Yingjiang Zhou and Scott, {William T.} and Bhavna Paratala and Tod Turner and Andrew Smith and Barbara Bernardo and M{\"u}ller, {Christian P.} and Hao Tang and Mangelsdorf, {David J.} and Bryan Goodwin and Kliewer, {Steven A.}",

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AU - Talukdar, Saswata

AU - Owen, Bryn M.

AU - Song, Parkyong

AU - Hernandez, Genaro

AU - Zhang, Yuan

AU - Zhou, Yingjiang

AU - Scott, William T.

AU - Paratala, Bhavna

AU - Turner, Tod

AU - Smith, Andrew

AU - Bernardo, Barbara

AU - Müller, Christian P.

AU - Tang, Hao

AU - Mangelsdorf, David J.

AU - Goodwin, Bryan

AU - Kliewer, Steven A.

PY - 2016/2/9

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AB - Fibroblast growth factor 21 (FGF21) is a hormone induced by various metabolic stresses, including ketogenic and high-carbohydrate diets, that regulates energy homeostasis. In humans, SNPs in and around the FGF21 gene have been associated with macronutrient preference, including carbohydrate, fat, and protein intake. Here we show that FGF21 administration markedly reduces sweet and alcohol preference in mice and sweet preference in cynomolgus monkeys. In mice, these effects require the FGF21 co-receptor β-Klotho in the central nervous system and correlate with reductions in dopamine concentrations in the nucleus accumbens. Since analogs of FGF21 are currently undergoing clinical evaluation for the treatment of obesity and type 2 diabetes, our findings raise the possibility that FGF21 administration could affect nutrient preference and other reward behaviors in humans.

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FGF21 regulates sweet and alcohol preference

Abstract

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