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Fibroblast state switching orchestrates dermal maturation and wound healing

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Fibroblast state switching orchestrates dermal maturation and wound healing. / Rognoni, Emanuel; Pisco, Angela Oliveira; Hiratsuka, Toru; Sipilä, Kalle H.; Belmonte, Julio M.; Mobasseri, Seyedeh Atefeh; Philippeos, Christina; Dilão, Rui; Watt, Fiona M.

In: Molecular Systems Biology, Vol. 14, No. 8, e8174, 08.2018.

Research output: Contribution to journalArticle

Harvard

Rognoni, E, Pisco, AO, Hiratsuka, T, Sipilä, KH, Belmonte, JM, Mobasseri, SA, Philippeos, C, Dilão, R & Watt, FM 2018, 'Fibroblast state switching orchestrates dermal maturation and wound healing', Molecular Systems Biology, vol. 14, no. 8, e8174. https://doi.org/10.15252/msb.20178174

APA

Rognoni, E., Pisco, A. O., Hiratsuka, T., Sipilä, K. H., Belmonte, J. M., Mobasseri, S. A., ... Watt, F. M. (2018). Fibroblast state switching orchestrates dermal maturation and wound healing. Molecular Systems Biology, 14(8), [e8174]. https://doi.org/10.15252/msb.20178174

Vancouver

Rognoni E, Pisco AO, Hiratsuka T, Sipilä KH, Belmonte JM, Mobasseri SA et al. Fibroblast state switching orchestrates dermal maturation and wound healing. Molecular Systems Biology. 2018 Aug;14(8). e8174. https://doi.org/10.15252/msb.20178174

Author

Rognoni, Emanuel ; Pisco, Angela Oliveira ; Hiratsuka, Toru ; Sipilä, Kalle H. ; Belmonte, Julio M. ; Mobasseri, Seyedeh Atefeh ; Philippeos, Christina ; Dilão, Rui ; Watt, Fiona M. / Fibroblast state switching orchestrates dermal maturation and wound healing. In: Molecular Systems Biology. 2018 ; Vol. 14, No. 8.

Bibtex Download

@article{e1a74587203b4f44b436120c844d294a,
title = "Fibroblast state switching orchestrates dermal maturation and wound healing",
abstract = "Murine dermis contains functionally and spatially distinct fibroblast lineages that cease to proliferate in early postnatal life. Here, we propose a model in which a negative feedback loop between extracellular matrix (ECM) deposition and fibroblast proliferation determines dermal architecture. Virtual-tissue simulations of our model faithfully recapitulate dermal maturation, predicting a loss of spatial segregation of fibroblast lineages and dictating that fibroblast migration is only required for wound healing. To test this, we performed in vivo live imaging of dermal fibroblasts, which revealed that homeostatic tissue architecture is achieved without active cell migration. In contrast, both fibroblast proliferation and migration are key determinants of tissue repair following wounding. The results show that tissue-scale coordination is driven by the interdependence of cell proliferation and ECM deposition, paving the way for identifying new therapeutic strategies to enhance skin regeneration.",
keywords = "dermis development, fibroblast states, mathematical modelling, tissue architecture, wound healing",
author = "Emanuel Rognoni and Pisco, {Angela Oliveira} and Toru Hiratsuka and Sipil{\"a}, {Kalle H.} and Belmonte, {Julio M.} and Mobasseri, {Seyedeh Atefeh} and Christina Philippeos and Rui Dil{\~a}o and Watt, {Fiona M.}",
note = "{\circledC} 2018 The Authors. Published under the terms of the CC BY 4.0 license.",
year = "2018",
month = "8",
doi = "10.15252/msb.20178174",
language = "English",
volume = "14",
journal = "Molecular Systems Biology",
issn = "1744-4292",
publisher = "Wiley-Blackwell",
number = "8",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Fibroblast state switching orchestrates dermal maturation and wound healing

AU - Rognoni, Emanuel

AU - Pisco, Angela Oliveira

AU - Hiratsuka, Toru

AU - Sipilä, Kalle H.

AU - Belmonte, Julio M.

AU - Mobasseri, Seyedeh Atefeh

AU - Philippeos, Christina

AU - Dilão, Rui

AU - Watt, Fiona M.

N1 - © 2018 The Authors. Published under the terms of the CC BY 4.0 license.

PY - 2018/8

Y1 - 2018/8

N2 - Murine dermis contains functionally and spatially distinct fibroblast lineages that cease to proliferate in early postnatal life. Here, we propose a model in which a negative feedback loop between extracellular matrix (ECM) deposition and fibroblast proliferation determines dermal architecture. Virtual-tissue simulations of our model faithfully recapitulate dermal maturation, predicting a loss of spatial segregation of fibroblast lineages and dictating that fibroblast migration is only required for wound healing. To test this, we performed in vivo live imaging of dermal fibroblasts, which revealed that homeostatic tissue architecture is achieved without active cell migration. In contrast, both fibroblast proliferation and migration are key determinants of tissue repair following wounding. The results show that tissue-scale coordination is driven by the interdependence of cell proliferation and ECM deposition, paving the way for identifying new therapeutic strategies to enhance skin regeneration.

AB - Murine dermis contains functionally and spatially distinct fibroblast lineages that cease to proliferate in early postnatal life. Here, we propose a model in which a negative feedback loop between extracellular matrix (ECM) deposition and fibroblast proliferation determines dermal architecture. Virtual-tissue simulations of our model faithfully recapitulate dermal maturation, predicting a loss of spatial segregation of fibroblast lineages and dictating that fibroblast migration is only required for wound healing. To test this, we performed in vivo live imaging of dermal fibroblasts, which revealed that homeostatic tissue architecture is achieved without active cell migration. In contrast, both fibroblast proliferation and migration are key determinants of tissue repair following wounding. The results show that tissue-scale coordination is driven by the interdependence of cell proliferation and ECM deposition, paving the way for identifying new therapeutic strategies to enhance skin regeneration.

KW - dermis development

KW - fibroblast states

KW - mathematical modelling

KW - tissue architecture

KW - wound healing

UR - http://www.scopus.com/inward/record.url?scp=85052525824&partnerID=8YFLogxK

U2 - 10.15252/msb.20178174

DO - 10.15252/msb.20178174

M3 - Article

C2 - 30158243

AN - SCOPUS:85052525824

VL - 14

JO - Molecular Systems Biology

JF - Molecular Systems Biology

SN - 1744-4292

IS - 8

M1 - e8174

ER -

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