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Fifteen-minute consultation: Liver disease in children

Research output: Contribution to journalArticlepeer-review

Jake P. Mann, Kathy Gallagher, Emer Fitzpatrick, Anil Dhawan

Original languageEnglish
Pages (from-to)170-176
Number of pages7
JournalArchives of Disease in Childhood: Education and Practice Edition
Issue number4
Early online date9 Nov 2017
Accepted/In press15 Oct 2017
E-pub ahead of print9 Nov 2017
Published1 Aug 2018


King's Authors


Liver disease in children can present in many ways from the frequently encountered prolonged neonatal jaundice to the comparatively rare acute liver failure. In this article, we will discuss 'red flags' of liver disease, the initial investigations required and when to refer to a specialist liver centre. Across all presentations, the degree of elevation of alanine aminotransferase or aspartate aminotransferase provides only little diagnostic information. Measurement of clotting is vital, and coagulopathy should be followed by a trial of intravenous vitamin K before being repeated.

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