Fifty years on: Serotonin and depression

Sameer Jauhar, Philip J Cowen, Michael Browning

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


It has been over 50 years since the original serotonin hypothesis was proposed by the British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the hypothesis. In this narrative review, we summarise the evidence for the serotonin hypothesis of depression, focusing on psychopharmacology and molecular imaging, as well as systems-level neuroscience.

Original languageEnglish
Article number2698811231161813
Pages (from-to)237-241
Number of pages5
JournalJournal of psychopharmacology (Oxford, England)
Issue number3
Early online date20 Mar 2023
Publication statusPublished - Mar 2023


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