TY - JOUR
T1 - First-Episode Psychosis Patients Who Deteriorated in the Premorbid Period Do Not Have Higher Polygenic Risk Scores Than Others
T2 - A Cluster Analysis of EU-GEI Data
AU - WP2 EU-GEI Group
AU - Ferraro, Laura
AU - Quattrone, Diego
AU - La Barbera, Daniele
AU - La Cascia, Caterina
AU - Morgan, Craig
AU - Kirkbride, James B.
AU - Cardno, Alastair G.
AU - Sham, Pak
AU - Tripoli, Giada
AU - Sideli, Lucia
AU - Seminerio, Fabio
AU - Sartorio, Crocettarachele
AU - Szoke, Andrei
AU - Tarricone, Ilaria
AU - Bernardo, Miquel
AU - Rodriguez, Victoria
AU - Stilo, Simona A.
AU - Gayer-Anderson, Charlotte
AU - de Haan, Lieuwe
AU - Velthorst, Eva
AU - Jongsma, Hannah
AU - Bart, Rutten B.P.
AU - Richards, Alexander
AU - Arango, Celso
AU - Menezez, Paulo Rossi
AU - Lasalvia, Antonio
AU - Tosato, Sarah
AU - Tortelli, Andrea
AU - Del Ben, Cristina Marta
AU - Selten, Jean Paul
AU - Jones, Peter B.
AU - van Os, Jim
AU - Di Forti, Marta
AU - Vassos, Evangelos
AU - Murray, Robin M.
N1 - Publisher Copyright:
© The Author(s) 2022. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.
PY - 2023/1/3
Y1 - 2023/1/3
N2 - Cluster studies identified a subgroup of patients with psychosis whose premorbid adjustment deteriorates before the onset, which may reflect variation in genetic influence. However, other studies reported a complex relationship between distinctive patterns of cannabis use and cognitive and premorbid impairment that is worthy of consideration. We examined whether: (1) premorbid social functioning (PSF) and premorbid academic functioning (PAF) in childhood and adolescence and current intellectual quotient (IQ) define different clusters in 802 first-episode of psychosis (FEP) patients; resulting clusters vary in (2) polygenic risk scores (PRSs) for schizophrenia (SCZ_PRS), bipolar disorder (BD_PRS), major depression (MD_PRS), and IQ (IQ_PRS), and (3) patterns of cannabis use, compared to 1,263 population-based controls. Four transdiagnostic clusters emerged (BIC = 2268.5): (1) high-cognitive-functioning (n = 205), with the highest IQ (Mean = 106.1, 95% CI: 104.3, 107.9) and PAF, but low PSF. (2) Low-cognitive-functioning (n = 223), with the lowest IQ (Mean = 73.9, 95% CI: 72.2, 75.7) and PAF, but normal PSF. (3) Intermediate (n = 224) (Mean_IQ = 80.8, 95% CI: 79.1, 82.5) with low-improving PAF and PSF. 4) Deteriorating (n = 150) (Mean_IQ = 80.6, 95% CI: 78.5, 82.7), with normal-deteriorating PAF and PSF. The PRSs explained 7.9% of between-group membership. FEP had higher SCZ_PRS than controls [F(4,1319) = 20.4, P < .001]. Among the clusters, the deteriorating group had lower SCZ_PRS and was likelier to have used high-potency cannabis daily. Patients with FEP clustered according to their premorbid and cognitive abilities. Pronounced premorbid deterioration was not typical of most FEP, including those more strongly predisposed to schizophrenia, but appeared in a cluster with a history of high-potency cannabis use.
AB - Cluster studies identified a subgroup of patients with psychosis whose premorbid adjustment deteriorates before the onset, which may reflect variation in genetic influence. However, other studies reported a complex relationship between distinctive patterns of cannabis use and cognitive and premorbid impairment that is worthy of consideration. We examined whether: (1) premorbid social functioning (PSF) and premorbid academic functioning (PAF) in childhood and adolescence and current intellectual quotient (IQ) define different clusters in 802 first-episode of psychosis (FEP) patients; resulting clusters vary in (2) polygenic risk scores (PRSs) for schizophrenia (SCZ_PRS), bipolar disorder (BD_PRS), major depression (MD_PRS), and IQ (IQ_PRS), and (3) patterns of cannabis use, compared to 1,263 population-based controls. Four transdiagnostic clusters emerged (BIC = 2268.5): (1) high-cognitive-functioning (n = 205), with the highest IQ (Mean = 106.1, 95% CI: 104.3, 107.9) and PAF, but low PSF. (2) Low-cognitive-functioning (n = 223), with the lowest IQ (Mean = 73.9, 95% CI: 72.2, 75.7) and PAF, but normal PSF. (3) Intermediate (n = 224) (Mean_IQ = 80.8, 95% CI: 79.1, 82.5) with low-improving PAF and PSF. 4) Deteriorating (n = 150) (Mean_IQ = 80.6, 95% CI: 78.5, 82.7), with normal-deteriorating PAF and PSF. The PRSs explained 7.9% of between-group membership. FEP had higher SCZ_PRS than controls [F(4,1319) = 20.4, P < .001]. Among the clusters, the deteriorating group had lower SCZ_PRS and was likelier to have used high-potency cannabis daily. Patients with FEP clustered according to their premorbid and cognitive abilities. Pronounced premorbid deterioration was not typical of most FEP, including those more strongly predisposed to schizophrenia, but appeared in a cluster with a history of high-potency cannabis use.
KW - bipolar
KW - cannabis
KW - deterioration
KW - IQ
KW - premorbid
KW - schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=85145491863&partnerID=8YFLogxK
U2 - 10.1093/schbul/sbac100
DO - 10.1093/schbul/sbac100
M3 - Article
C2 - 35947471
AN - SCOPUS:85145491863
SN - 0586-7614
VL - 49
SP - 218
EP - 227
JO - Schizophrenia bulletin
JF - Schizophrenia bulletin
IS - 1
ER -