TY - JOUR
T1 - First Human In Vivo Neuroelectrophysiology Recordings of Uncrossed Dentatothalamocortical White-Matter Connections
T2 - On the Fast Tract
AU - Brogna, Christian
AU - Perera, Noemia
AU - Ghimire, Prajwal
AU - Bruchhage, Muriel M.K.
AU - Abela, Eugenio
AU - Richardson, Mark P.
AU - Vergani, Francesco
AU - Bhangoo, Ranjeev
AU - Ashkan, Keyoumars
N1 - Publisher Copyright:
© American Academy of Neurology.
PY - 2022/8/23
Y1 - 2022/8/23
N2 - ObjectivesWe aim to demonstrate intraoperative recording of cerebellar to cortical pathways that have not been previously recorded in humans, though imaged.MethodsWe report 2 cases with intraoperative neurophysiologic mapping of cerebellocortical tracts. Direct electrical stimulation of subcortical cerebellum along with recordings of cortical evoked potential and motor muscle recordings was performed during surgery. MR tractography data from healthy participants were used to further illustrate the pathways.ResultsNeurophysiologic recordings showed large waveforms of evoked potentials in bilateral electrodes over premotor/motor cortices on stimulation of the dentate nucleus. EMG recordings showed responses in face and neck muscles on stimulation of the dentate nucleus at the motor threshold. We thus demonstrated first-in-human in vivo neurophysiologic evidence of cerebellum to cortex responses through an uncrossed dentatothalamocortical tract to the motor/premotor cortices.DiscussionThis technique provides a methodology for the direct mapping of the cerebellum and cerebello-cerebral connections. We hypothesize a direct structural connection from the dentate nucleus to the premotor and motor cortices, as well as to ipsilateral hemibody muscles, acting as a fast route of cerebellar output and back up for immediate motor responses. This will further help explain the modulatory effects of the cerebellum on motor, language, and cognitive functions.
AB - ObjectivesWe aim to demonstrate intraoperative recording of cerebellar to cortical pathways that have not been previously recorded in humans, though imaged.MethodsWe report 2 cases with intraoperative neurophysiologic mapping of cerebellocortical tracts. Direct electrical stimulation of subcortical cerebellum along with recordings of cortical evoked potential and motor muscle recordings was performed during surgery. MR tractography data from healthy participants were used to further illustrate the pathways.ResultsNeurophysiologic recordings showed large waveforms of evoked potentials in bilateral electrodes over premotor/motor cortices on stimulation of the dentate nucleus. EMG recordings showed responses in face and neck muscles on stimulation of the dentate nucleus at the motor threshold. We thus demonstrated first-in-human in vivo neurophysiologic evidence of cerebellum to cortex responses through an uncrossed dentatothalamocortical tract to the motor/premotor cortices.DiscussionThis technique provides a methodology for the direct mapping of the cerebellum and cerebello-cerebral connections. We hypothesize a direct structural connection from the dentate nucleus to the premotor and motor cortices, as well as to ipsilateral hemibody muscles, acting as a fast route of cerebellar output and back up for immediate motor responses. This will further help explain the modulatory effects of the cerebellum on motor, language, and cognitive functions.
UR - http://www.scopus.com/inward/record.url?scp=85137402803&partnerID=8YFLogxK
U2 - 10.1212/WNL.0000000000200990
DO - 10.1212/WNL.0000000000200990
M3 - Article
C2 - 35794017
AN - SCOPUS:85137402803
SN - 0028-3878
VL - 99
SP - 332
EP - 335
JO - Neurology
JF - Neurology
IS - 8
ER -
