First trimester maternal uterine artery Doppler examination in HIV-positive women

M. D. Savvidou; M. I. Samuel; R. Akolekar; Mary Poulton; K. H. Nicolaides

doi:10.1111/j.1468-1293.2011.00930.x

First trimester maternal uterine artery Doppler examination in HIV-positive women

M. D. Savvidou^*, M. I. Samuel, R. Akolekar, Mary Poulton, K. H. Nicolaides

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Objectives

The aim of the current study was to assess the effect of maternal HIV infection, treated or untreated, on the degree of placental invasion, as assessed by the pulsatility index of the uterine arteries during a Doppler examination at 11(+0)-13(+6) weeks' gestation.

Methods

This was a nested case-control study in which a uterine artery Doppler examination was performed in the first trimester in 76 HIV-positive women. Each woman was matched with 30 HIV-negative women. As the pulsatility index of the uterine arteries depends on a number of maternal and fetal characteristics, its values in each case and control were expressed as multiples of the median (MoM) of the unaffected group.

Results

Among the 76 HIV-positive women, 33 (43.4%) were on antiretroviral treatment at the time of the Doppler examination, including 14 women (42.4%) on nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor, 18 women (54.5%) on NRTIs and a nonnucleoside reverse transcriptase inhibitor and one woman (3.1%) on monotherapy. Compared with the HIV-negative women, the HIV-positive women were more likely to be heavier (P <0.01), to be of African origin (P <0.01), to be nonsmokers (P=0.01) and to deliver smaller neonates earlier (P <0.01). The median adjusted pulsatility index of the uterine arteries was not statistically different between the cases and controls [1.07; interquartile range (IQR) 0.85-1.24 MoM vs. 0.99; IQR 0.81-1.20 MoM; P = 0.28] or, in HIV-positive women, between those receiving and not receiving antiretroviral treatment (P=0.12).

Conclusions

HIV-positive women with uncomplicated pregnancies have normal placental perfusion in the first trimester of pregnancy.

Original language	English
Pages (from-to)	632-636
Number of pages	5
Journal	HIV MEDICINE
Volume	12
Issue number	10
DOIs	https://doi.org/10.1111/j.1468-1293.2011.00930.x
Publication status	Published - Nov 2011

Keywords

Doppler examination
HIV
pregnancy
uterine artery
IMMUNODEFICIENCY-VIRUS-INFECTION
ACTIVE ANTIRETROVIRAL THERAPY
PREECLAMPSIA
PREDICTION
STIFFNESS
RISK

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1468-1293.2011.00930.x

Cite this

@article{c84966d61c664508942d4c6dd1ca7cec,

title = "First trimester maternal uterine artery Doppler examination in HIV-positive women",

abstract = "ObjectivesThe aim of the current study was to assess the effect of maternal HIV infection, treated or untreated, on the degree of placental invasion, as assessed by the pulsatility index of the uterine arteries during a Doppler examination at 11(+0)-13(+6) weeks' gestation.MethodsThis was a nested case-control study in which a uterine artery Doppler examination was performed in the first trimester in 76 HIV-positive women. Each woman was matched with 30 HIV-negative women. As the pulsatility index of the uterine arteries depends on a number of maternal and fetal characteristics, its values in each case and control were expressed as multiples of the median (MoM) of the unaffected group.ResultsAmong the 76 HIV-positive women, 33 (43.4%) were on antiretroviral treatment at the time of the Doppler examination, including 14 women (42.4%) on nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor, 18 women (54.5%) on NRTIs and a nonnucleoside reverse transcriptase inhibitor and one woman (3.1%) on monotherapy. Compared with the HIV-negative women, the HIV-positive women were more likely to be heavier (P <0.01), to be of African origin (P <0.01), to be nonsmokers (P=0.01) and to deliver smaller neonates earlier (P <0.01). The median adjusted pulsatility index of the uterine arteries was not statistically different between the cases and controls [1.07; interquartile range (IQR) 0.85-1.24 MoM vs. 0.99; IQR 0.81-1.20 MoM; P = 0.28] or, in HIV-positive women, between those receiving and not receiving antiretroviral treatment (P=0.12).ConclusionsHIV-positive women with uncomplicated pregnancies have normal placental perfusion in the first trimester of pregnancy.",

keywords = "Doppler examination, HIV, pregnancy, uterine artery, IMMUNODEFICIENCY-VIRUS-INFECTION, ACTIVE ANTIRETROVIRAL THERAPY, PREECLAMPSIA, PREDICTION, STIFFNESS, RISK",

author = "Savvidou, {M. D.} and Samuel, {M. I.} and R. Akolekar and Mary Poulton and Nicolaides, {K. H.}",

year = "2011",

month = nov,

doi = "10.1111/j.1468-1293.2011.00930.x",

language = "English",

volume = "12",

pages = "632--636",

journal = "HIV MEDICINE",

issn = "1464-2662",

publisher = "Wiley-Blackwell",

number = "10",

}

TY - JOUR

T1 - First trimester maternal uterine artery Doppler examination in HIV-positive women

AU - Savvidou, M. D.

AU - Samuel, M. I.

AU - Akolekar, R.

AU - Poulton, Mary

AU - Nicolaides, K. H.

PY - 2011/11

Y1 - 2011/11

N2 - ObjectivesThe aim of the current study was to assess the effect of maternal HIV infection, treated or untreated, on the degree of placental invasion, as assessed by the pulsatility index of the uterine arteries during a Doppler examination at 11(+0)-13(+6) weeks' gestation.MethodsThis was a nested case-control study in which a uterine artery Doppler examination was performed in the first trimester in 76 HIV-positive women. Each woman was matched with 30 HIV-negative women. As the pulsatility index of the uterine arteries depends on a number of maternal and fetal characteristics, its values in each case and control were expressed as multiples of the median (MoM) of the unaffected group.ResultsAmong the 76 HIV-positive women, 33 (43.4%) were on antiretroviral treatment at the time of the Doppler examination, including 14 women (42.4%) on nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor, 18 women (54.5%) on NRTIs and a nonnucleoside reverse transcriptase inhibitor and one woman (3.1%) on monotherapy. Compared with the HIV-negative women, the HIV-positive women were more likely to be heavier (P <0.01), to be of African origin (P <0.01), to be nonsmokers (P=0.01) and to deliver smaller neonates earlier (P <0.01). The median adjusted pulsatility index of the uterine arteries was not statistically different between the cases and controls [1.07; interquartile range (IQR) 0.85-1.24 MoM vs. 0.99; IQR 0.81-1.20 MoM; P = 0.28] or, in HIV-positive women, between those receiving and not receiving antiretroviral treatment (P=0.12).ConclusionsHIV-positive women with uncomplicated pregnancies have normal placental perfusion in the first trimester of pregnancy.

AB - ObjectivesThe aim of the current study was to assess the effect of maternal HIV infection, treated or untreated, on the degree of placental invasion, as assessed by the pulsatility index of the uterine arteries during a Doppler examination at 11(+0)-13(+6) weeks' gestation.MethodsThis was a nested case-control study in which a uterine artery Doppler examination was performed in the first trimester in 76 HIV-positive women. Each woman was matched with 30 HIV-negative women. As the pulsatility index of the uterine arteries depends on a number of maternal and fetal characteristics, its values in each case and control were expressed as multiples of the median (MoM) of the unaffected group.ResultsAmong the 76 HIV-positive women, 33 (43.4%) were on antiretroviral treatment at the time of the Doppler examination, including 14 women (42.4%) on nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor, 18 women (54.5%) on NRTIs and a nonnucleoside reverse transcriptase inhibitor and one woman (3.1%) on monotherapy. Compared with the HIV-negative women, the HIV-positive women were more likely to be heavier (P <0.01), to be of African origin (P <0.01), to be nonsmokers (P=0.01) and to deliver smaller neonates earlier (P <0.01). The median adjusted pulsatility index of the uterine arteries was not statistically different between the cases and controls [1.07; interquartile range (IQR) 0.85-1.24 MoM vs. 0.99; IQR 0.81-1.20 MoM; P = 0.28] or, in HIV-positive women, between those receiving and not receiving antiretroviral treatment (P=0.12).ConclusionsHIV-positive women with uncomplicated pregnancies have normal placental perfusion in the first trimester of pregnancy.

KW - Doppler examination

KW - HIV

KW - pregnancy

KW - uterine artery

KW - IMMUNODEFICIENCY-VIRUS-INFECTION

KW - ACTIVE ANTIRETROVIRAL THERAPY

KW - PREECLAMPSIA

KW - PREDICTION

KW - STIFFNESS

KW - RISK

U2 - 10.1111/j.1468-1293.2011.00930.x

DO - 10.1111/j.1468-1293.2011.00930.x

M3 - Article

SN - 1464-2662

VL - 12

SP - 632

EP - 636

JO - HIV MEDICINE

JF - HIV MEDICINE

IS - 10

ER -

First trimester maternal uterine artery Doppler examination in HIV-positive women

Abstract

Keywords

UN SDGs

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