First use of preimplantation genotyping in prevention of recurrent diandric complete hydatidiform mole

C. Mackie Ogilvie; P. J. Renwick; Y. Khalaf; P. R. Braude

First use of preimplantation genotyping in prevention of recurrent diandric complete hydatidiform mole

C. Mackie Ogilvie, P. J. Renwick, Y. Khalaf, P. R. Braude

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Complete hydatidiform moles have a diploid chromosome constitution, generally with only paternal genetic material present (diandry). Diandric complete moles are thought to arise either by fertilization of an anucleate oocyte by two spermatozoa or. more commonly, doubling of a single sperm genotype. Molar pregnancies are usually sporadic, and may be accompanied by malignant transformation; however, recurrence is associated with increased risk of further affected pregnancies and of persistent trophoblastic neoplasia or choriocarcinoma. This study presents the first use of preimplantation genotyping to ensure biparental inheritance in a woman presenting with recurrent diandric complete hydatidiform mole. Following an IVF cycle, a single cell from each of I I embryos was tested by whole genome amplification and genotyping at 16 different simple tandem repeat loci. All embryos showed normal biparental inheritance; one blastocyst was transferred, resulting in the delivery of healthy monozygotic twin girls.

Original language	English
Pages (from-to)	224 - 227
Number of pages	4
Journal	REPRODUCTIVE BIOMEDICINE ONLINE
Volume	19
Issue number	2
Publication status	Published - Aug 2009

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title = "First use of preimplantation genotyping in prevention of recurrent diandric complete hydatidiform mole",

abstract = "Complete hydatidiform moles have a diploid chromosome constitution, generally with only paternal genetic material present (diandry). Diandric complete moles are thought to arise either by fertilization of an anucleate oocyte by two spermatozoa or. more commonly, doubling of a single sperm genotype. Molar pregnancies are usually sporadic, and may be accompanied by malignant transformation; however, recurrence is associated with increased risk of further affected pregnancies and of persistent trophoblastic neoplasia or choriocarcinoma. This study presents the first use of preimplantation genotyping to ensure biparental inheritance in a woman presenting with recurrent diandric complete hydatidiform mole. Following an IVF cycle, a single cell from each of I I embryos was tested by whole genome amplification and genotyping at 16 different simple tandem repeat loci. All embryos showed normal biparental inheritance; one blastocyst was transferred, resulting in the delivery of healthy monozygotic twin girls.",

author = "Ogilvie, {C. Mackie} and Renwick, {P. J.} and Y. Khalaf and Braude, {P. R.}",

year = "2009",

month = aug,

language = "English",

volume = "19",

pages = "224 -- 227",

journal = "REPRODUCTIVE BIOMEDICINE ONLINE",

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T1 - First use of preimplantation genotyping in prevention of recurrent diandric complete hydatidiform mole

AU - Ogilvie, C. Mackie

AU - Renwick, P. J.

AU - Khalaf, Y.

AU - Braude, P. R.

PY - 2009/8

Y1 - 2009/8

N2 - Complete hydatidiform moles have a diploid chromosome constitution, generally with only paternal genetic material present (diandry). Diandric complete moles are thought to arise either by fertilization of an anucleate oocyte by two spermatozoa or. more commonly, doubling of a single sperm genotype. Molar pregnancies are usually sporadic, and may be accompanied by malignant transformation; however, recurrence is associated with increased risk of further affected pregnancies and of persistent trophoblastic neoplasia or choriocarcinoma. This study presents the first use of preimplantation genotyping to ensure biparental inheritance in a woman presenting with recurrent diandric complete hydatidiform mole. Following an IVF cycle, a single cell from each of I I embryos was tested by whole genome amplification and genotyping at 16 different simple tandem repeat loci. All embryos showed normal biparental inheritance; one blastocyst was transferred, resulting in the delivery of healthy monozygotic twin girls.

AB - Complete hydatidiform moles have a diploid chromosome constitution, generally with only paternal genetic material present (diandry). Diandric complete moles are thought to arise either by fertilization of an anucleate oocyte by two spermatozoa or. more commonly, doubling of a single sperm genotype. Molar pregnancies are usually sporadic, and may be accompanied by malignant transformation; however, recurrence is associated with increased risk of further affected pregnancies and of persistent trophoblastic neoplasia or choriocarcinoma. This study presents the first use of preimplantation genotyping to ensure biparental inheritance in a woman presenting with recurrent diandric complete hydatidiform mole. Following an IVF cycle, a single cell from each of I I embryos was tested by whole genome amplification and genotyping at 16 different simple tandem repeat loci. All embryos showed normal biparental inheritance; one blastocyst was transferred, resulting in the delivery of healthy monozygotic twin girls.

M3 - Article

VL - 19

SP - 224

EP - 227

JO - REPRODUCTIVE BIOMEDICINE ONLINE

JF - REPRODUCTIVE BIOMEDICINE ONLINE

IS - 2

ER -

First use of preimplantation genotyping in prevention of recurrent diandric complete hydatidiform mole

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