Flexible Microfluidic Fabrication of Oil-Encapsulated Alginate Microfibers

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Abstract

A unified microfluidic approach is presented for flexible fabrication of oil-encapsulated calcium alginate microfibers. The oil encapsulate phase was directly injected into the gelling alginate fiber, thus allowing the adjustable tuning of the encapsulate geometry ranging from spherical to prolate ellipsoid, plug-like and tubular shapes. Phase maps were developed that show the conditions required to achieve desired fiber morphologies with intended encapsulate phase ratio. We also show for very first time how oil encapsulates can be selectively grouped across the microfibers. A force-balance model was introduced to predict the size of spherical encapsulates.
Original languageEnglish
Pages (from-to)1090-1097
JournalCHEMICAL ENGINEERING JOURNAL
Volume308
Early online date16 Sept 2016
DOIs
Publication statusPublished - 15 Jan 2017

Keywords

  • Microfluidics
  • Alginate microfibers
  • Encapsulation

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