Flow-induced dilatation in isolated resistance arteries from control and streptozotocin-diabetic rats

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25 Citations (Scopus)


Acetylcholine-induced vasodilatation is impaired in animal models of insulin-dependent diabetes mellitus (IDDM), and may result from altered nitric oxide synthesis or release. The response to intraluminal flow, a more physiologically relevant stimulus for nitric oxide release, is unknown. This study examined flow-induced responses in isolated resistance arteries from male Sprague-Dawley control and streptozotocin-diabetic (45 mg/kg i.v., 4 week duration) rats. Mesenteric arteries (4-5th order) were dissected and cannulated on a pressure myograph (mean internal diameter +/- SEM at 40 mmHg, control 223 +/- 8, n = 9 vs diabetic 239 +/- 12 microm, n = 8, NS). Arteries were preconstricted with noradrenaline (1 micromol/l) and intraluminal pressure raised and maintained at 80 mmHg. Luminal flow was raised in incremental steps (0-1.27 microl/s). Arteries from control animals dilated to flow while arteries from diabetic animals constricted (% change in internal diameter +/- SEM at 0.79 microl/s: control 13.46 +/- 6.52, n = 9 vs diabetic -7.44 +/- 3.38%, n = 8; p
Original languageEnglish
Pages (from-to)34-39
Number of pages6
Issue number1
Publication statusPublished - Jan 1998


  • Acetylcholine
  • Animals
  • Blood Flow Velocity
  • Diabetes Mellitus, Experimental
  • Intestine, Small
  • Male
  • Mesenteric Arteries
  • Muscle, Smooth, Vascular
  • NG-Nitroarginine Methyl Ester
  • Norepinephrine
  • Rats
  • Rats, Sprague-Dawley
  • Reference Values
  • Stress, Mechanical
  • Vasodilation


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