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Flow velocity mapping using contrast enhanced high-frame-rate plane wave ultrasound and image tracking: Methods and initial in vitro and in vivo evaluation

Research output: Contribution to journalArticle

Chee Hau Leow, Eleni Bazigou, Robert J. Eckersley, Alfred C H Yu, Peter D. Weinberg, Meng Xing Tang

Original languageEnglish
Pages (from-to)2913-2925
Number of pages13
JournalUltrasound in medicine & biology
Volume41
Issue number11
DOIs
Accepted/In press16 Jun 2015
Published1 Nov 2015

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Abstract

Ultrasound imaging is the most widely used method for visualising and quantifying blood flow in medical practice, but existing techniques have various limitations in terms of imaging sensitivity, field of view, flow angle dependence, and imaging depth. In this study, we developed an ultrasound imaging velocimetry approach capable of visualising and quantifying dynamic flow, by combining high-frame-rate plane wave ultrasound imaging, microbubble contrast agents, pulse inversion contrast imaging and speckle image tracking algorithms. The system was initially evaluated in vitro on both straight and carotid-mimicking vessels with steady and pulsatile flows and in vivo in the rabbit aorta. Colour and spectral Doppler measurements were also made. Initial flow mapping results were compared with theoretical prediction and reference Doppler measurements and indicate the potential of the new system as a highly sensitive, accurate, angle-independent and full field-of-view velocity mapping tool capable of tracking and quantifying fast and dynamic flows.

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