Fluorescent CXCR4 chemokine receptor antagonists: Metal activated binding

Abid Khan; Jon D. Silversides; Leigh Madden; John Greenman; Stephen J. Archibald

doi:10.1039/b614557d

Fluorescent CXCR4 chemokine receptor antagonists: Metal activated binding

Abid Khan, Jon D. Silversides, Leigh Madden, John Greenman, Stephen J. Archibald^*

^*Corresponding author for this work

Imaging Chemistry & Biology

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

The copper(ii) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.

Original language	English
Pages (from-to)	416-418
Number of pages	3
Journal	Chemical Communications
Issue number	4
DOIs	https://doi.org/10.1039/b614557d
Publication status	Published - 2007

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10.1039/b614557d

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@article{0929a20fb3134963aa4db9652a127cfd,

title = "Fluorescent CXCR4 chemokine receptor antagonists: Metal activated binding",

abstract = "The copper(ii) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.",

author = "Abid Khan and Silversides, {Jon D.} and Leigh Madden and John Greenman and Archibald, {Stephen J.}",

year = "2007",

doi = "10.1039/b614557d",

language = "English",

pages = "416--418",

journal = "Chemical Communications",

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T1 - Fluorescent CXCR4 chemokine receptor antagonists

T2 - Metal activated binding

AU - Khan, Abid

AU - Silversides, Jon D.

AU - Madden, Leigh

AU - Greenman, John

AU - Archibald, Stephen J.

PY - 2007

Y1 - 2007

N2 - The copper(ii) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.

AB - The copper(ii) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.

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U2 - 10.1039/b614557d

DO - 10.1039/b614557d

M3 - Article

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AN - SCOPUS:33846254107

SN - 1359-7345

SP - 416

EP - 418

JO - Chemical Communications

JF - Chemical Communications

IS - 4

ER -

Fluorescent CXCR4 chemokine receptor antagonists: Metal activated binding

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