Fluorogenic displacement biosensors for PSA detection using antibody-functionalised quantum dot nanoparticles

Nunzianda Frascione; James Gooch; Vincenzo Abbate; Barbara Daniel

doi:10.1039/c4ra14066d

Fluorogenic displacement biosensors for PSA detection using antibody-functionalised quantum dot nanoparticles

Nunzianda Frascione^*, James Gooch, Vincenzo Abbate, Barbara Daniel

^*Corresponding author for this work

King's College London

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Novel quantum dot conjugated immunosensors are presented for the accurate identification of seminal fluid in forensic casework. The production of a fluorescence signal upon the displacement of moderately bound quencher-labelled peptide analogues by Prostate Specific Antigen (PSA) overcomes many of the practical disadvantages associated with traditional lateral flow cartridge testing.

Original language	English
Pages (from-to)	6595-6598
Number of pages	4
Journal	RSC Advances
Volume	5
Issue number	9
Early online date	18 Dec 2014
DOIs	https://doi.org/10.1039/c4ra14066d
Publication status	Published - 2015

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10.1039/c4ra14066d

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title = "Fluorogenic displacement biosensors for PSA detection using antibody-functionalised quantum dot nanoparticles",

abstract = "Novel quantum dot conjugated immunosensors are presented for the accurate identification of seminal fluid in forensic casework. The production of a fluorescence signal upon the displacement of moderately bound quencher-labelled peptide analogues by Prostate Specific Antigen (PSA) overcomes many of the practical disadvantages associated with traditional lateral flow cartridge testing.",

author = "Nunzianda Frascione and James Gooch and Vincenzo Abbate and Barbara Daniel",

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T1 - Fluorogenic displacement biosensors for PSA detection using antibody-functionalised quantum dot nanoparticles

AU - Frascione, Nunzianda

AU - Gooch, James

AU - Abbate, Vincenzo

AU - Daniel, Barbara

PY - 2015

Y1 - 2015

N2 - Novel quantum dot conjugated immunosensors are presented for the accurate identification of seminal fluid in forensic casework. The production of a fluorescence signal upon the displacement of moderately bound quencher-labelled peptide analogues by Prostate Specific Antigen (PSA) overcomes many of the practical disadvantages associated with traditional lateral flow cartridge testing.

AB - Novel quantum dot conjugated immunosensors are presented for the accurate identification of seminal fluid in forensic casework. The production of a fluorescence signal upon the displacement of moderately bound quencher-labelled peptide analogues by Prostate Specific Antigen (PSA) overcomes many of the practical disadvantages associated with traditional lateral flow cartridge testing.

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U2 - 10.1039/c4ra14066d

DO - 10.1039/c4ra14066d

M3 - Article

AN - SCOPUS:84920856293

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SP - 6595

EP - 6598

JO - RSC Advances

JF - RSC Advances

IS - 9

ER -

Fluorogenic displacement biosensors for PSA detection using antibody-functionalised quantum dot nanoparticles

Abstract

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