Focused Ultrasound Induced Hyperthermia Accelerates and Increases the Uptake of anti-Her2 Antibodies in a Xenograft Model

Miguel N. Centelles, Michael Wright, Wladyslaw Gedroyc, Maya Thanou

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)
218 Downloads (Pure)

Abstract

Abstract
Image guided drug delivery has gained significant attention during the last few years. Labelling nanoparticles or macromolecules and monitoring their fate in the body provides information that can be used to modulate their biodistribution and improve their pharmacokinetics. In this study we label antibodies and monitor their distribution in the tumours post intravenous injection. Using Focused Ultrasound (FUS, a non-invasive method of hyperthermia) we increase the tumour temperature to 42 °C for a short period of time (3–5 min) and we observe an increased accumulation of labelled antibody. Repetition of focused ultrasound induced hyperthermic treatment increased still further the accumulation of the antibodies in the tumour. This treatment also augmented the accumulation of other macromolecules non-specific in the tumour, such as IgG and albumin. These effects may be used to enhance the therapeutic efficiency of antibodies and/or targeted nanoparticles.
Original languageEnglish
JournalPharmacological Research
Early online date19 Oct 2016
DOIs
Publication statusE-pub ahead of print - 19 Oct 2016

Keywords

  • focused ultrasound
  • Trastuzumab
  • Herceptin
  • in vivo imaging
  • antibody therapy
  • cancer

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