Foetal brain development in offspring of women with psychosis

TY - JOUR

T1 - Foetal brain development in offspring of women with psychosis

AU - Clarke, M C

AU - Cannon, M

AU - Hogg, M

AU - Marks, M N

AU - Conroy, Susan

AU - Pawlby, S J

AU - Greenough, A

AU - Nicolaides, K

PY - 2007/5

Y1 - 2007/5

N2 - Cerebral ventricular enlargement and reduced cortical volume are correlates of chronic schizophrenia. We investigated whether genetic risk for psychosis is related to differences in foetal brain development as measured by prenatal ultrasonography. Routine foetal cerebral measures at 19-23 weeks of gestation were compared between the offspring of 35 women with a history of psychosis and 105 control women matched for gestational age. Overall, no significant differences were found between the high-risk and control groups. There was a non-significant trend in the adjusted analysis towards increased lateral ventricular width in the offspring of mothers with psychosis

AB - Cerebral ventricular enlargement and reduced cortical volume are correlates of chronic schizophrenia. We investigated whether genetic risk for psychosis is related to differences in foetal brain development as measured by prenatal ultrasonography. Routine foetal cerebral measures at 19-23 weeks of gestation were compared between the offspring of 35 women with a history of psychosis and 105 control women matched for gestational age. Overall, no significant differences were found between the high-risk and control groups. There was a non-significant trend in the adjusted analysis towards increased lateral ventricular width in the offspring of mothers with psychosis

U2 - 10.1192/bjp.bp.106.023747

DO - 10.1192/bjp.bp.106.023747

M3 - Article

SN - 1472-1465

VL - 190

SP - 445

EP - 446

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

IS - MAY

ER -