Folding scene investigation: membrane proteins

TY - JOUR

T1 - Folding scene investigation

T2 - membrane proteins

AU - Booth, Paula J

AU - Curnow, Paul

PY - 2009/2

Y1 - 2009/2

N2 - Investigations into protein folding have concentrated on experimentally tractable proteins with the result that membrane protein folding remains unsolved. New evidence is providing insight into the nature of the interactions stabilising the folded state of alpha-helical membrane proteins as well as giving hints on the character of the folding transition state. These developments show that classical methods used for water-soluble proteins can be successfully adapted for membrane proteins. The advances, coupled with increasing numbers of solved crystal structures, augur well for future research into the mechanisms of membrane protein folding.

AB - Investigations into protein folding have concentrated on experimentally tractable proteins with the result that membrane protein folding remains unsolved. New evidence is providing insight into the nature of the interactions stabilising the folded state of alpha-helical membrane proteins as well as giving hints on the character of the folding transition state. These developments show that classical methods used for water-soluble proteins can be successfully adapted for membrane proteins. The advances, coupled with increasing numbers of solved crystal structures, augur well for future research into the mechanisms of membrane protein folding.

KW - Animals

KW - Humans

KW - Kinetics

KW - Lipid Bilayers

KW - Membrane Proteins

KW - Models, Biological

KW - Protein Folding

KW - Protein Structure, Secondary

KW - Thermodynamics

U2 - 10.1016/j.sbi.2008.12.005

DO - 10.1016/j.sbi.2008.12.005

M3 - Article

C2 - 19157854

SN - 0959-440X

VL - 19

SP - 8

EP - 13

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

IS - 1

ER -