TY - JOUR
T1 - Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects
T2 - A 12-Year Prospective Study
AU - González-Domínguez, Raúl
AU - Castellano-Escuder, Pol
AU - Carmona, Francisco
AU - Lefèvre-Arbogast, Sophie
AU - Low, Dorrain Y.
AU - Du Preez, Andrea
AU - Ruigrok, Silvie R.
AU - Manach, Claudine
AU - Urpi-Sarda, Mireia
AU - Korosi, Aniko
AU - Lucassen, Paul J.
AU - Aigner, Ludwig
AU - Pallàs, Mercè
AU - Thuret, Sandrine
AU - Samieri, Cécilia
AU - Sánchez-Pla, Alex
AU - Andres-Lacueva, Cristina
N1 - Funding Information:
This work was accomplished as a part of the D-CogPlast project (?Identification of dietary modulators of cognitive ageing and brain plasticity and proof of concept of efficacy for preventing/reversing cognitive decline?) supported within the European Joint Programming Initiative ?A Healthy Diet for a Healthy Life? (JPI HDHL, http://www.healthydietforhealthylife.eu/), granted by MINECO (Spain, PCIN-2015-229), ANR (France, ANR-15-HDHL-0002-05) and the Medical Research Council UK (UK, MR/N030087/1). This work also received funding from the JPI-HDHL ERA-Net Cofund on INtesTInal MICrobiomics (ERA-HDHL INTIMIC, AC19/00096), CIBERFES funded by Instituto de Salud Carlos III and co-funded by the European Regional Development Fund ?A way to make Europe?, and the Generalitat de Catalunya's Agency AGAUR (2017SGR1546). RGD thanks the ?Juan de la Cierva? program from MINECO (FJCI-2015-26590) and CAL the ICREA Academia award 2018. Aniko Korosi is supported by NWO and Alzheimer Nederland, Paul Lucassen by the UvA Urban Mental Health program and Alzheimer Nederland, Sophie Lef?vre-Arbogast was part of the University Research school (Ecole Universitaire de Recherche, EUR) Digital Public Health PhD program, supported within the framework of the French National Research Agency (ANR) ?Programme d'Investissement d'Avenir? (Investment for the Future) PIA3 (17-EURE-0019). The Three-City Study is conducted under a partnership agreement between the Institut National de la Sant? et de la Recherche M?dicale (INSERM), the Institut de Sant? Publique et D?veloppement of the Victor Segalen Bordeaux 2 University and Sanofi-Aventis. The Fondation pour la Recherche M?dicale funded the preparation and initiation of the study. The 3C Study is also supported by the Caisse Nationale Maladie des Travailleurs Salari?s, Direction G?n?rale de la Sant?, Mutuelle G?n?rale de l'Education Nationale, Institut de la Long?vit?, Regional Governments of Aquitaine and Bourgogne, Fondation de France, Ministry of Research-INSERM Programme ?Cohortes et collections de donn?es biologiques?, French National Research Agency COGINUT ANR-06-PNRA-005, the Fondation Plan Alzheimer (FCS 2009?2012), and the Caisse Nationale pour la Solidarit? et l'Autonomie (CNSA).
Funding Information:
This work was accomplished as a part of the D‐CogPlast project (“Identification of dietary modulators of cognitive ageing and brain plasticity and proof of concept of efficacy for preventing/reversing cognitive decline”) supported within the European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL, http:// www.healthydietforhealthylife.eu/ ), granted by MINECO (Spain, PCIN‐2015‐229), ANR (France, ANR‐15‐HDHL‐0002‐05) and the Medical Research Council UK (UK, MR/N030087/1). This work also received funding from the JPI‐HDHL ERA‐Net Cofund on INtesTInal MICrobiomics (ERA‐HDHL INTIMIC, AC19/00096), CIBERFES funded by Instituto de Salud Carlos III and co‐funded by the European Regional Development Fund “A way to make Europe”, and the Generalitat de Catalunya's Agency AGAUR (2017SGR1546). RGD thanks the “Juan de la Cierva” program from MINECO (FJCI‐2015‐26590) and CAL the ICREA Academia award 2018. Aniko Korosi is supported by NWO and Alzheimer Nederland, Paul Lucassen by the UvA Urban Mental Health program and Alzheimer Nederland, Sophie Lefèvre‐Arbogast was part of the University Research school (Ecole Universitaire de Recherche, EUR) Digital Public Health PhD program, supported within the framework of the French National Research Agency (ANR) “Programme d'Investissement d'Avenir” (Investment for the Future) PIA3 (17‐EURE‐0019). The Three‐City Study is conducted under a partnership agreement between the Institut National de la Santé et de la Recherche Médicale (INSERM), the Institut de Santé Publique et Développement of the Victor Segalen Bordeaux 2 University and Sanofi‐Aventis. The Fondation pour la Recherche Médicale funded the preparation and initiation of the study. The 3C Study is also supported by the Caisse Nationale Maladie des Travailleurs Salariés, Direction Générale de la Santé, Mutuelle Générale de l'Education Nationale, Institut de la Longévité, Regional Governments of Aquitaine and Bourgogne, Fondation de France, Ministry of Research‐INSERM Programme “Cohortes et collections de données biologiques”, French National Research Agency COGINUT ANR‐06‐PNRA‐005, the Fondation Plan Alzheimer (FCS 2009–2012), and the Caisse Nationale pour la Solidarité et l'Autonomie (CNSA).
Publisher Copyright:
© 2021 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH
PY - 2021/12
Y1 - 2021/12
N2 - Scope: Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented and often inconsistent. Methods and Results: The article studies the long-term prospective Three-City Cohort, which consists of two separate nested case-control sample sets from different geographic regions (Bordeaux, n = 418; Dijon, n = 424). Cognitive decline is evaluated through five neuropsychological tests (Mini-Mental State Examination, Benton Visual Retention Test, Isaac's Set Test, Trail-Making Test part A, and Trail-Making Test part B). The food-related and microbiota-derived circulating metabolome is studied in participants free of dementia at baseline, by subjecting serum samples to large-scale quantitative metabolomics analysis. A protective association is found between metabolites derived from cocoa, coffee, mushrooms, red wine, the microbial metabolism of polyphenol-rich foods, and cognitive decline, as well as a negative association with metabolites related to unhealthy dietary components, such as artificial sweeteners and alcohol. Conclusion: These results provide insight into the early metabolic events that are associated with the later risk to develop cognitive decline within the crosstalk between diet, gut microbiota and the endogenous metabolism, which can help identify potential targets for preventive and therapeutic strategies to preserve cognitive health.
AB - Scope: Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented and often inconsistent. Methods and Results: The article studies the long-term prospective Three-City Cohort, which consists of two separate nested case-control sample sets from different geographic regions (Bordeaux, n = 418; Dijon, n = 424). Cognitive decline is evaluated through five neuropsychological tests (Mini-Mental State Examination, Benton Visual Retention Test, Isaac's Set Test, Trail-Making Test part A, and Trail-Making Test part B). The food-related and microbiota-derived circulating metabolome is studied in participants free of dementia at baseline, by subjecting serum samples to large-scale quantitative metabolomics analysis. A protective association is found between metabolites derived from cocoa, coffee, mushrooms, red wine, the microbial metabolism of polyphenol-rich foods, and cognitive decline, as well as a negative association with metabolites related to unhealthy dietary components, such as artificial sweeteners and alcohol. Conclusion: These results provide insight into the early metabolic events that are associated with the later risk to develop cognitive decline within the crosstalk between diet, gut microbiota and the endogenous metabolism, which can help identify potential targets for preventive and therapeutic strategies to preserve cognitive health.
KW - cognitive decline
KW - diet
KW - food metabolome
KW - gut microbiota
KW - metabolomics
UR - http://www.scopus.com/inward/record.url?scp=85117900565&partnerID=8YFLogxK
U2 - 10.1002/mnfr.202100606
DO - 10.1002/mnfr.202100606
M3 - Article
AN - SCOPUS:85117900565
SN - 1613-4125
VL - 65
JO - Molecular Nutrition and Food Research
JF - Molecular Nutrition and Food Research
IS - 23
M1 - 2100606
ER -