Formal thought disorder in people at ultra-high risk of psychosis

TY - JOUR

T1 - Formal thought disorder in people at ultra-high risk of psychosis

AU - Demjaha, Arsime

AU - Weinstein, Sara

AU - Stahl, Daniel

AU - Day, Fern

AU - Valmaggia, Lucia

AU - Rutigliano, Grazia

AU - De Micheli, Andrea

AU - Fusar-Poli, Paolo

AU - McGuire, Philip

PY - 2017/7

Y1 - 2017/7

N2 - BACKGROUND: Formal thought disorder is a cardinal feature of psychosis. However, the extent to which formal thought disorder is evident in ultra-high-risk individuals and whether it is linked to the progression to psychosis remains unclear.AIMS: Examine the severity of formal thought disorder in ultra-high-risk participants and its association with future psychosis.METHOD: The Thought and Language Index (TLI) was used to assess 24 ultra-high-risk participants, 16 people with first-episode psychosis and 13 healthy controls. Ultra-high-risk individuals were followed up for a mean duration of 7 years (s.d.=1.5) to determine the relationship between formal thought disorder at baseline and transition to psychosis.RESULTS: TLI scores were significantly greater in the ultra-high-risk group compared with the healthy control group (effect size (ES)=1.2), but lower than in people with first-episode psychosis (ES=0.8). Total and negative TLI scores were higher in ultra-high-risk individuals who developed psychosis, but this was not significant. Combining negative TLI scores with attenuated psychotic symptoms and basic symptoms predicted transition to psychosis (P=0.04; ES=1.04).CONCLUSIONS: TLI is beneficial in evaluating formal thought disorder in ultra-high-risk participants, and complements existing instruments for the evaluation of psychopathology in this group.DECLARATION OF INTERESTS: None.COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2017. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.

AB - BACKGROUND: Formal thought disorder is a cardinal feature of psychosis. However, the extent to which formal thought disorder is evident in ultra-high-risk individuals and whether it is linked to the progression to psychosis remains unclear.AIMS: Examine the severity of formal thought disorder in ultra-high-risk participants and its association with future psychosis.METHOD: The Thought and Language Index (TLI) was used to assess 24 ultra-high-risk participants, 16 people with first-episode psychosis and 13 healthy controls. Ultra-high-risk individuals were followed up for a mean duration of 7 years (s.d.=1.5) to determine the relationship between formal thought disorder at baseline and transition to psychosis.RESULTS: TLI scores were significantly greater in the ultra-high-risk group compared with the healthy control group (effect size (ES)=1.2), but lower than in people with first-episode psychosis (ES=0.8). Total and negative TLI scores were higher in ultra-high-risk individuals who developed psychosis, but this was not significant. Combining negative TLI scores with attenuated psychotic symptoms and basic symptoms predicted transition to psychosis (P=0.04; ES=1.04).CONCLUSIONS: TLI is beneficial in evaluating formal thought disorder in ultra-high-risk participants, and complements existing instruments for the evaluation of psychopathology in this group.DECLARATION OF INTERESTS: None.COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2017. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.

KW - Journal Article

U2 - 10.1192/bjpo.bp.116.004408

DO - 10.1192/bjpo.bp.116.004408

M3 - Article

C2 - 28713586

SN - 2056-4724

VL - 3

SP - 165

EP - 170

JO - British Journal of Psychiatry Open

JF - British Journal of Psychiatry Open

IS - 4

ER -