Formation of Supramolecular Gels from Host–Guest Interactions between PEGylated Chitosan and α-Cyclodextrin

Kalliopi‐kelli A. Vandera; Charlotte Pague; Jasmin Omar; Gustavo González‐gaitano; Twana Mohammed M. Ways; Vitaliy V. Khutoryanskiy; Cécile A. Dreiss

doi:10.1002/mame.202200646

Formation of Supramolecular Gels from Host–Guest Interactions between PEGylated Chitosan and α-Cyclodextrin

Kalliopi‐kelli A. Vandera, Charlotte Pague, Jasmin Omar, Gustavo González‐gaitano, Twana Mohammed M. Ways, Vitaliy V. Khutoryanskiy, Cécile A. Dreiss

Institute of Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

20 Downloads (Pure)

Abstract

Chitosan-based hydrogels are prepared via the formation of polypseudorotaxanes (PPR), by selectively threading α-cyclodextrin (α-CD) macrocycles onto polymeric chains, which, through the formation of microcrystalline domains, act as junction points for the network. Specifically, host–guest inclusion complexes are formed between α-CD and PEGylated chitosan (PEG-Ch), resulting in the formation of supramolecular gels. PEG-grafted chitosan is obtained with a reaction yield of 79.8%, a high degree of grafting (50.9% GW) and water solubility (≈16 mg mL−1), as assessed by turbidimetry. A range of compositions for mixtures of PEG-Ch solutions (0.2–0.8% w/w) and α-CD solutions (2−12% w/w, or 0.04–0.2% mol) are studied. Regardless of PEG content, gels are not formed at low α-CD concentrations (

Original language	English
Article number	2200646
Journal	MACROMOLECULAR MATERIALS AND ENGINEERING
Volume	308
Issue number	6
Early online date	3 Feb 2023
DOIs	https://doi.org/10.1002/mame.202200646
Publication status	Published - Jun 2023

Access to Document

10.1002/mame.202200646Licence: CC BY

Macro Materials Eng - 2023 - Vandera - Formation of Supramolecular Gels from Host Guest Interactions between PEGylatedFinal published version, 2.28 MBLicence: CC BY

Cite this

@article{647c3ebe722943fd856f76157debb1b4,

title = "Formation of Supramolecular Gels from Host–Guest Interactions between PEGylated Chitosan and α-Cyclodextrin",

abstract = "Chitosan-based hydrogels are prepared via the formation of polypseudorotaxanes (PPR), by selectively threading α-cyclodextrin (α-CD) macrocycles onto polymeric chains, which, through the formation of microcrystalline domains, act as junction points for the network. Specifically, host–guest inclusion complexes are formed between α-CD and PEGylated chitosan (PEG-Ch), resulting in the formation of supramolecular gels. PEG-grafted chitosan is obtained with a reaction yield of 79.8%, a high degree of grafting (50.9% GW) and water solubility (≈16 mg mL−1), as assessed by turbidimetry. A range of compositions for mixtures of PEG-Ch solutions (0.2–0.8% w/w) and α-CD solutions (2−12% w/w, or 0.04–0.2% mol) are studied. Regardless of PEG content, gels are not formed at low α-CD concentrations (",

author = "Vandera, {Kalliopi‐kelli A.} and Charlotte Pague and Jasmin Omar and Gustavo Gonz{\'a}lez‐gaitano and Ways, {Twana Mohammed M.} and Khutoryanskiy, {Vitaliy V.} and Dreiss, {C{\'e}cile A.}",

note = "Funding Information: Erasmus the wonderful EU program to support education, training, youth and sport in Europe is acknowledged for funding the three‐month internship of C.P. at the Institute of Pharmaceutical Science, visiting from ENSIC (Universit{\'e} de Lorraine, France). Funding Information: Erasmus the wonderful EU program to support education, training, youth and sport in Europe is acknowledged for funding the three-month internship of C.P. at the Institute of Pharmaceutical Science, visiting from ENSIC (Universit{\'e} de Lorraine, France). Publisher Copyright: {\textcopyright} 2023 The Authors. Macromolecular Materials and Engineering published by Wiley-VCH GmbH.",

year = "2023",

month = jun,

doi = "10.1002/mame.202200646",

language = "English",

volume = "308",

journal = "MACROMOLECULAR MATERIALS AND ENGINEERING",

issn = "1438-7492",

publisher = "Wiley-VCH Verlag",

number = "6",

}

TY - JOUR

T1 - Formation of Supramolecular Gels from Host–Guest Interactions between PEGylated Chitosan and α-Cyclodextrin

AU - Vandera, Kalliopi‐kelli A.

AU - Pague, Charlotte

AU - Omar, Jasmin

AU - González‐gaitano, Gustavo

AU - Ways, Twana Mohammed M.

AU - Khutoryanskiy, Vitaliy V.

AU - Dreiss, Cécile A.

N1 - Funding Information: Erasmus the wonderful EU program to support education, training, youth and sport in Europe is acknowledged for funding the three‐month internship of C.P. at the Institute of Pharmaceutical Science, visiting from ENSIC (Université de Lorraine, France). Funding Information: Erasmus the wonderful EU program to support education, training, youth and sport in Europe is acknowledged for funding the three-month internship of C.P. at the Institute of Pharmaceutical Science, visiting from ENSIC (Université de Lorraine, France). Publisher Copyright: © 2023 The Authors. Macromolecular Materials and Engineering published by Wiley-VCH GmbH.

PY - 2023/6

Y1 - 2023/6

N2 - Chitosan-based hydrogels are prepared via the formation of polypseudorotaxanes (PPR), by selectively threading α-cyclodextrin (α-CD) macrocycles onto polymeric chains, which, through the formation of microcrystalline domains, act as junction points for the network. Specifically, host–guest inclusion complexes are formed between α-CD and PEGylated chitosan (PEG-Ch), resulting in the formation of supramolecular gels. PEG-grafted chitosan is obtained with a reaction yield of 79.8%, a high degree of grafting (50.9% GW) and water solubility (≈16 mg mL−1), as assessed by turbidimetry. A range of compositions for mixtures of PEG-Ch solutions (0.2–0.8% w/w) and α-CD solutions (2−12% w/w, or 0.04–0.2% mol) are studied. Regardless of PEG content, gels are not formed at low α-CD concentrations (

AB - Chitosan-based hydrogels are prepared via the formation of polypseudorotaxanes (PPR), by selectively threading α-cyclodextrin (α-CD) macrocycles onto polymeric chains, which, through the formation of microcrystalline domains, act as junction points for the network. Specifically, host–guest inclusion complexes are formed between α-CD and PEGylated chitosan (PEG-Ch), resulting in the formation of supramolecular gels. PEG-grafted chitosan is obtained with a reaction yield of 79.8%, a high degree of grafting (50.9% GW) and water solubility (≈16 mg mL−1), as assessed by turbidimetry. A range of compositions for mixtures of PEG-Ch solutions (0.2–0.8% w/w) and α-CD solutions (2−12% w/w, or 0.04–0.2% mol) are studied. Regardless of PEG content, gels are not formed at low α-CD concentrations (

UR - http://www.scopus.com/inward/record.url?scp=85147435070&partnerID=8YFLogxK

U2 - 10.1002/mame.202200646

DO - 10.1002/mame.202200646

M3 - Article

SN - 1438-7492

VL - 308

JO - MACROMOLECULAR MATERIALS AND ENGINEERING

JF - MACROMOLECULAR MATERIALS AND ENGINEERING

IS - 6

M1 - 2200646

ER -

Formation of Supramolecular Gels from Host–Guest Interactions between PEGylated Chitosan and α-Cyclodextrin

Abstract

Access to Document

Other files and links

Fingerprint

Cite this