Formation of Supramolecular Gels from Host–Guest Interactions between PEGylated Chitosan and α-Cyclodextrin

Kalliopi‐kelli A. Vandera, Charlotte Pague, Jasmin Omar, Gustavo González‐gaitano, Twana Mohammed M. Ways, Vitaliy V. Khutoryanskiy, Cécile A. Dreiss

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
59 Downloads (Pure)

Abstract

Chitosan-based hydrogels are prepared via the formation of polypseudorotaxanes (PPR), by selectively threading α-cyclodextrin (α-CD) macrocycles onto polymeric chains, which, through the formation of microcrystalline domains, act as junction points for the network. Specifically, host–guest inclusion complexes are formed between α-CD and PEGylated chitosan (PEG-Ch), resulting in the formation of supramolecular gels. PEG-grafted chitosan is obtained with a reaction yield of 79.8%, a high degree of grafting (50.9% GW) and water solubility (≈16 mg mL−1), as assessed by turbidimetry. A range of compositions for mixtures of PEG-Ch solutions (0.2–0.8% w/w) and α-CD solutions (2−12% w/w, or 0.04–0.2% mol) are studied. Regardless of PEG content, gels are not formed at low α-CD concentrations (
Original languageEnglish
Article number2200646
JournalMACROMOLECULAR MATERIALS AND ENGINEERING
Volume308
Issue number6
Early online date3 Feb 2023
DOIs
Publication statusPublished - Jun 2023

Fingerprint

Dive into the research topics of 'Formation of Supramolecular Gels from Host–Guest Interactions between PEGylated Chitosan and α-Cyclodextrin'. Together they form a unique fingerprint.

Cite this