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Fostering in mice induces cardiovascular and metabolic dysfunction in adulthood

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Fostering in mice induces cardiovascular and metabolic dysfunction in adulthood. / Matthews, Phillippa A.; Samuelsson, Anne-Maj; Seed, Paul; Pombo, Joaquim; Oben, Jude A.; Poston, Lucilla; Taylor, Paul D.

In: The Journal of Physiology, Vol. 589, No. 16, 08.2011, p. 3969 - 3981.

Research output: Contribution to journalArticle

Harvard

Matthews, PA, Samuelsson, A-M, Seed, P, Pombo, J, Oben, JA, Poston, L & Taylor, PD 2011, 'Fostering in mice induces cardiovascular and metabolic dysfunction in adulthood', The Journal of Physiology, vol. 589, no. 16, pp. 3969 - 3981. https://doi.org/10.1113/jphysiol.2011.212324

APA

Matthews, P. A., Samuelsson, A-M., Seed, P., Pombo, J., Oben, J. A., Poston, L., & Taylor, P. D. (2011). Fostering in mice induces cardiovascular and metabolic dysfunction in adulthood. The Journal of Physiology, 589(16), 3969 - 3981. https://doi.org/10.1113/jphysiol.2011.212324

Vancouver

Matthews PA, Samuelsson A-M, Seed P, Pombo J, Oben JA, Poston L et al. Fostering in mice induces cardiovascular and metabolic dysfunction in adulthood. The Journal of Physiology. 2011 Aug;589(16):3969 - 3981. https://doi.org/10.1113/jphysiol.2011.212324

Author

Matthews, Phillippa A. ; Samuelsson, Anne-Maj ; Seed, Paul ; Pombo, Joaquim ; Oben, Jude A. ; Poston, Lucilla ; Taylor, Paul D. / Fostering in mice induces cardiovascular and metabolic dysfunction in adulthood. In: The Journal of Physiology. 2011 ; Vol. 589, No. 16. pp. 3969 - 3981.

Bibtex Download

@article{fe96ed39f4774cfeb84cc6e3d1b1409c,
title = "Fostering in mice induces cardiovascular and metabolic dysfunction in adulthood",
abstract = "Cross-fostering is widely used in developmental programming studies to determine the relative contribution of the in utero and suckling periods in establishing the adult offspring phenotype in response to an environmental challenge. We have investigated whether the process of fostering per se influences cardiovascular and metabolic function in adult offspring of C57BL/6J mice in comparison with animals suckled by their biological dams. Cross-fostered (CF) mice demonstrated juvenile onset hyperphagia and significantly higher body weight (from weaning to 12 weeks: male control (CON) vs. CF: P <0.01, female CON vs. CF: P <0.001; RM ANOVA) accompanied by increased abdominal adiposity in males only (white adipose tissue mass (mg): CON 280.5 +/- 13.4 [mean +/- SEM] (n = 7) vs. CF, 549.8 +/- 99.3 (n = 8), P <0.01). Both male and female CF mice demonstrated significantly enhanced glucose tolerance. A marked increase in systolic blood pressure (SBP) was observed in male CF mice (SBP (mmHg), day: CON 100.5 +/- 1.4 (n = 6) vs. CF 114.3 +/- 0.7 (n = 6), P <0.001; night: CON 108.0 +/- 2.0 (n = 6) vs. CF 123.2 +/- 1.1 (n = 6), P <0.001). Endothelium-dependent relaxation was enhanced in male CFmice, and renal noradrenaline was increased in female CF mice. Concentration of serum triglycerides, cholesterol, insulin and leptin were increased in CF vs. CON. The process of cross-fostering profoundly affects cardiovascular and metabolic phenotype in mice. The findings have implications for the inclusion of appropriate controls in the design of future studies and in the interpretation of previous cross-fostering studies in mice.",
author = "Matthews, {Phillippa A.} and Anne-Maj Samuelsson and Paul Seed and Joaquim Pombo and Oben, {Jude A.} and Lucilla Poston and Taylor, {Paul D.}",
year = "2011",
month = "8",
doi = "10.1113/jphysiol.2011.212324",
language = "English",
volume = "589",
pages = "3969 -- 3981",
journal = "The Journal of Physiology",
issn = "0022-3751",
number = "16",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Fostering in mice induces cardiovascular and metabolic dysfunction in adulthood

AU - Matthews, Phillippa A.

AU - Samuelsson, Anne-Maj

AU - Seed, Paul

AU - Pombo, Joaquim

AU - Oben, Jude A.

AU - Poston, Lucilla

AU - Taylor, Paul D.

PY - 2011/8

Y1 - 2011/8

N2 - Cross-fostering is widely used in developmental programming studies to determine the relative contribution of the in utero and suckling periods in establishing the adult offspring phenotype in response to an environmental challenge. We have investigated whether the process of fostering per se influences cardiovascular and metabolic function in adult offspring of C57BL/6J mice in comparison with animals suckled by their biological dams. Cross-fostered (CF) mice demonstrated juvenile onset hyperphagia and significantly higher body weight (from weaning to 12 weeks: male control (CON) vs. CF: P <0.01, female CON vs. CF: P <0.001; RM ANOVA) accompanied by increased abdominal adiposity in males only (white adipose tissue mass (mg): CON 280.5 +/- 13.4 [mean +/- SEM] (n = 7) vs. CF, 549.8 +/- 99.3 (n = 8), P <0.01). Both male and female CF mice demonstrated significantly enhanced glucose tolerance. A marked increase in systolic blood pressure (SBP) was observed in male CF mice (SBP (mmHg), day: CON 100.5 +/- 1.4 (n = 6) vs. CF 114.3 +/- 0.7 (n = 6), P <0.001; night: CON 108.0 +/- 2.0 (n = 6) vs. CF 123.2 +/- 1.1 (n = 6), P <0.001). Endothelium-dependent relaxation was enhanced in male CFmice, and renal noradrenaline was increased in female CF mice. Concentration of serum triglycerides, cholesterol, insulin and leptin were increased in CF vs. CON. The process of cross-fostering profoundly affects cardiovascular and metabolic phenotype in mice. The findings have implications for the inclusion of appropriate controls in the design of future studies and in the interpretation of previous cross-fostering studies in mice.

AB - Cross-fostering is widely used in developmental programming studies to determine the relative contribution of the in utero and suckling periods in establishing the adult offspring phenotype in response to an environmental challenge. We have investigated whether the process of fostering per se influences cardiovascular and metabolic function in adult offspring of C57BL/6J mice in comparison with animals suckled by their biological dams. Cross-fostered (CF) mice demonstrated juvenile onset hyperphagia and significantly higher body weight (from weaning to 12 weeks: male control (CON) vs. CF: P <0.01, female CON vs. CF: P <0.001; RM ANOVA) accompanied by increased abdominal adiposity in males only (white adipose tissue mass (mg): CON 280.5 +/- 13.4 [mean +/- SEM] (n = 7) vs. CF, 549.8 +/- 99.3 (n = 8), P <0.01). Both male and female CF mice demonstrated significantly enhanced glucose tolerance. A marked increase in systolic blood pressure (SBP) was observed in male CF mice (SBP (mmHg), day: CON 100.5 +/- 1.4 (n = 6) vs. CF 114.3 +/- 0.7 (n = 6), P <0.001; night: CON 108.0 +/- 2.0 (n = 6) vs. CF 123.2 +/- 1.1 (n = 6), P <0.001). Endothelium-dependent relaxation was enhanced in male CFmice, and renal noradrenaline was increased in female CF mice. Concentration of serum triglycerides, cholesterol, insulin and leptin were increased in CF vs. CON. The process of cross-fostering profoundly affects cardiovascular and metabolic phenotype in mice. The findings have implications for the inclusion of appropriate controls in the design of future studies and in the interpretation of previous cross-fostering studies in mice.

U2 - 10.1113/jphysiol.2011.212324

DO - 10.1113/jphysiol.2011.212324

M3 - Article

VL - 589

SP - 3969

EP - 3981

JO - The Journal of Physiology

JF - The Journal of Physiology

SN - 0022-3751

IS - 16

ER -

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