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Fractional Flow Reserve and Myocardial Perfusion Imaging in Patients With Angiographic Multivessel Coronary Artery Disease

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Narbeh Melikian, Pieter De Bondt, Pim Tonino, Olivier De Winter, Eric Wyffels, Jozef Bartunek, Guy R. Heyndrickx, William F. Fearon, Nico H. J. Pijls, William Wijns, Bernard De Bruyne

Original languageEnglish
Pages (from-to)307 - 314
Number of pages8
JournalJacc-Cardiovascular Interventions
Issue number3
PublishedMar 2010

King's Authors


Objectives The aim of this study was to investigate the correlation between myocardial ischemia detected by myocardial perfusion imaging (MPI) with single-photon emission computed tomography with intracoronary pressure-derived fractional flow reserve (FFR) in patients with multivessel coronary disease at angiography. Background Myocardial perfusion imaging can underestimate the number of ischemic territories in patients with multivessel disease. However, there are limited data comparing MPI and FFR, a highly accurate functional index of myocardial ischemia, in multivessel coronary disease. Methods Sixty-seven patients (201 vascular territories) with angiographic 2- or 3-vessel coronary disease were prospectively scheduled to undergo within 2 weeks MPI (rest/stress adenosine) and FFR in each vessel. Results In 42% of patients, MPI and FFR detected identical ischemic territories (mean number of territories 0.9 +/- 0.8 for both; p = 1.00). In the remaining 36% MPI underestimated (mean number of territories; MPI: 0.46 +/- 0.6, FFR: 2.0 +/- 0.6; p

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