Frailty in Older Adults with Mild Dementia: Dementia with Lewy Bodies and Alzheimer's Disease

Miguel Germán Borda; Hogne Soennesyn; Claire J. Steves; Audun Osland Vik-Mo; Mario Ulises Pérez-Zepeda; Dag Aarsland

doi:10.1159/000496537

Frailty in Older Adults with Mild Dementia: Dementia with Lewy Bodies and Alzheimer's Disease

Miguel Germán Borda^*, Hogne Soennesyn, Claire J. Steves, Audun Osland Vik-Mo, Mario Ulises Pérez-Zepeda, Dag Aarsland

^*Corresponding author for this work

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27 Citations (Scopus)

Abstract

>bold<>italic<Introduction:>/italic<>/bold< The aim of the study is to describe the frequency of frailty in people with a new diagnosis of mild dementia due to Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). >bold<>italic<Methods:>/italic<>/bold< This is a secondary analysis of the Dementia Study of Western Norway (Demvest). For this study, we analysed a sample of 186 patients, 116 with AD and 70 with DLB. Subjects were included at a time in which mild dementia was diagnosed according to consensus criteria after comprehensive standardized assessment. Frailty was evaluated retrospectively using a frailty index generated from existing data. The cut-off value used to classify an older adult as frail was 0.25. >bold<>italic<Results:>/italic<>/bold< The prevalence of frailty was 25.81% (>italic<n>/italic< = 48). In the DLB group, 37.14% (>italic<n>/italic< = 26) were classified as frail, compared to 18.97% (>italic<n>/italic< = 22) of those with AD (>italic

/italic< < 0.001). The adjusted multivariate analysis revealed an OR of 2.45 (1.15-5.23) for being frail in those with DLB when using AD as the reference group. >bold<>italic<Conclusion:>/italic<>/bold< Frailty was higher than expected in both types of dementia. The prevalence of frailty was higher in those with DLB compared to AD. This new finding underscores the need for a multi-systems approach in both dementias, with a particular focus on DLB.

Original language	English
Pages (from-to)	176-183
Number of pages	8
Journal	Dementia and Geriatric Cognitive Disorders Extra
Volume	9
Issue number	1
DOIs	https://doi.org/10.1159/000496537
Publication status	Published - 1 Jan 2019

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abstract = ">bold<>italic/italic<>/bold< The aim of the study is to describe the frequency of frailty in people with a new diagnosis of mild dementia due to Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). >bold<>italic/italic<>/bold< This is a secondary analysis of the Dementia Study of Western Norway (Demvest). For this study, we analysed a sample of 186 patients, 116 with AD and 70 with DLB. Subjects were included at a time in which mild dementia was diagnosed according to consensus criteria after comprehensive standardized assessment. Frailty was evaluated retrospectively using a frailty index generated from existing data. The cut-off value used to classify an older adult as frail was 0.25. >bold<>italic/italic<>/bold< The prevalence of frailty was 25.81% (>italic/italic< = 48). In the DLB group, 37.14% (>italic/italic< = 26) were classified as frail, compared to 18.97% (>italic/italic< = 22) of those with AD (>italic/italic< < 0.001). The adjusted multivariate analysis revealed an OR of 2.45 (1.15-5.23) for being frail in those with DLB when using AD as the reference group. >bold<>italic/italic<>/bold< Frailty was higher than expected in both types of dementia. The prevalence of frailty was higher in those with DLB compared to AD. This new finding underscores the need for a multi-systems approach in both dementias, with a particular focus on DLB.",

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AU - Pérez-Zepeda, Mario Ulises

AU - Aarsland, Dag

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Frailty in Older Adults with Mild Dementia: Dementia with Lewy Bodies and Alzheimer's Disease

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