TY - JOUR
T1 - Frailty in Parkinson's disease and its association with early dementia: A longitudinal study
AU - Borda, Miguel Germán
AU - Pérez-Zepeda, Mario Ulises
AU - Jaramillo-Jimenez, Alberto
AU - Chaudhuri, K. Ray
AU - Tovar-Rios, Diego Alejandro
AU - Wallace, Lindsay
AU - Batzu, Lucia
AU - Rockwood, Kenneth
AU - Tysnes, Ole Bjørn
AU - Aarsland, Dag
AU - Alves, Guido
N1 - Funding Information:
This paper represents independent research supported by the Norwegian government, through hospital owner Helse Vest ( Western Norway Regional Health Authority ). Also, funded by the National Institute for Health Research ( NIHR ) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London . The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care. LW is supported by a Canadian Institutes of Health Research Banting Postdoctoral Fellowship award.
Publisher Copyright:
© 2022 The Authors
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Introduction: Frailty is recognized as a clinical condition associated with increased vulnerability for developing negative health outcomes but has been little studied in patients with Parkinson's disease (PD). Here, we investigated the risk of frailty in de novo PD patients and its association with subsequent development of dementia. Methods: We conducted a three-year longitudinal population-based study of 192 drug-naive newly diagnosed PD patients and 172 controls (No-PD) matched for age, sex, and education. Frailty was measured using the frailty index (FI). Logistic regression models, adjusting for potential confounders, were conducted to assess the association between frailty at the time of PD diagnosis and the subsequent odds for developing PD dementia during follow-up. Results: The mean baseline FI score was higher in the PD (0.21 ± 0.10) than in the No-PD group (0.11 ± 0.07, p < 0.001). One-third of PD patients had high-FI (>0,25), compared to 5% in the no-PD group. Participants with PD had an increased risk to present frailty with an odds ratio (OR) of 6.68 (SE 2.70 IC 95% [3.15; 15.62], p-value
AB - Introduction: Frailty is recognized as a clinical condition associated with increased vulnerability for developing negative health outcomes but has been little studied in patients with Parkinson's disease (PD). Here, we investigated the risk of frailty in de novo PD patients and its association with subsequent development of dementia. Methods: We conducted a three-year longitudinal population-based study of 192 drug-naive newly diagnosed PD patients and 172 controls (No-PD) matched for age, sex, and education. Frailty was measured using the frailty index (FI). Logistic regression models, adjusting for potential confounders, were conducted to assess the association between frailty at the time of PD diagnosis and the subsequent odds for developing PD dementia during follow-up. Results: The mean baseline FI score was higher in the PD (0.21 ± 0.10) than in the No-PD group (0.11 ± 0.07, p < 0.001). One-third of PD patients had high-FI (>0,25), compared to 5% in the no-PD group. Participants with PD had an increased risk to present frailty with an odds ratio (OR) of 6.68 (SE 2.70 IC 95% [3.15; 15.62], p-value
KW - Dementia
KW - Frailty
KW - Older adults
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=85130845620&partnerID=8YFLogxK
U2 - 10.1016/j.parkreldis.2022.05.004
DO - 10.1016/j.parkreldis.2022.05.004
M3 - Article
C2 - 35598420
AN - SCOPUS:85130845620
SN - 1353-8020
VL - 99
SP - 51
EP - 57
JO - Parkinsonism & Related Disorders
JF - Parkinsonism & Related Disorders
ER -