Frailty modifications and prognostic impact in older patients admitted in acute care

Giorgio Basile, Antonino Catalano, Giuseppe Mandraffino, Giuseppe Maltese, Angela Alibrandi, Giuliana Ciancio, Daniela Brischetto, Nunziata Morabito, Antonino Lasco, Matteo Cesari

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Background Frailty is a predictor of adverse outcomes in older subjects. Aims The aims of this study are to (1) measure the frailty status and its changes occurring during the hospital stay, (2) determine the relationships among frailty and adverse outcomes. Methods Frailty was assessed using a 46-item Frailty Index (FI) in 156 patients admitted to an Acute Geriatric Medicine Unit. The FI was calculated within 24 h from the hospital admission (aFI) and at his/her discharge (dFI). Patients were followed up to 12 months after the hospital discharge. Results A statistically significant difference was reported between the aFI (0.31, IQR 0.19–0.44) and the dFI (0.29, IQR 0.19–0.40; p = 0.04). The aFI was directly associated with the risk of in-hospital death (OR = 5.9; 95% CI 2.0–17.5; p = 0.001), 1 year mortality (OR = 5.5, 95% CI 2.4–12.7, p < 0.001) and re-hospitalization (OR = 6.3, 95% CI 2.2–17.9, p = 0.03). Conclusion Frailty is a strong predictor of negative endpoints in hospitalized older persons. Discussion Frailty assessment from routinely collected clinical data may provide important insights about the biological status of the individual and promote the personalization of care.
Original languageEnglish
Pages (from-to)151-155
JournalAging Clinical and Experimental Research
Issue number1
Early online date26 Jun 2018
Publication statusPublished - 25 Jan 2019


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