Free-running Cardiac Magnetic Resonance Fingerprinting: Joint T1/T2 map and CINE imaging

Olivier Francois Jaubert, Gastao Jose Lima da Cruz, Aurelien Bustin, Torben Schneider, Peter Koken, Mariya Doneva, Daniel Rueckert, Rene Michael Botnar, Claudia Prieto Vasquez

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)
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PURPOSE: To develop and evaluate a novel non-ECG triggered 2D magnetic resonance fingerprinting (MRF) sequence allowing for simultaneous myocardial T1 and T2 mapping and cardiac Cine imaging. METHODS: Cardiac MRF (cMRF) has been recently proposed to provide joint T1/T2 myocardial mapping by triggering the acquisition to mid-diastole and relying on a subject-dependent dictionary of MR signal evolutions to generate the maps. In this work, we propose a novel “free-running” (non-ECG triggered) cMRF framework for simultaneous myocardial T1 and T2 mapping and cardiac Cine imaging in a single scan. Free-running cMRF is based on a transient state bSSFP acquisition with tiny golden angle radial readouts, varying flip angle and multiple adiabatic inversion pulses. The acquired data is retrospectively gated into several cardiac phases, which are reconstructed with an approach that combines parallel imaging, low rank modelling and patch-based high-order tensor regularization. Free-running cMRF was evaluated in a standardized phantom and ten healthy subjects. Comparison with reference spin-echo, MOLLI, SASHA, T2-GRASE and Cine was performed. RESULTS: T1 and T2 values obtained with the proposed approach were in good agreement with reference phantom values (ICC(A,1)>0.99). Reported values for myocardium septum T1 were 1043±48ms, 1150±100ms and 1160±79ms for MOLLI, SASHA and free-running cMRF respectively and for T2 of 51.7±4.1ms and 44.6±4.1ms for T2-GRASE and free-running cMRF respectively. Good agreement was observed between free-running cMRF and conventional Cine 2D ejection fraction (bias=-0.83%). CONCLUSION: The proposed free-running cardiac MRF approach allows for simultaneous assessment of myocardial T1 and T2 and Cine imaging in a single scan.
Original languageEnglish
Article numberMRI_9383
Pages (from-to)173-182
Number of pages10
JournalMagnetic resonance imaging
Early online date13 Feb 2020
Publication statusPublished - 1 May 2020


  • Cardiac MRI
  • Dynamic cine imaging
  • MR fingerprinting
  • T1 mapping
  • T2 mapping


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