Freeze-dried bilberry (Vaccinium myrtillus) dietary supplement improves walking distance and lipids after myocardial infarction. An open-label randomized clinical trial

Lilith  Arevström; Cecilia  Bergh; Rikard  Landberg; Huaxing Wu; Ana Maria Rodriguez Mateos; Micael   Waldenborg; Anders  Magnuson; Stepháne  Blanc; Ole  Fröberta

doi:10.1016/j.nutres.2018.11.008

Freeze-dried bilberry (Vaccinium myrtillus) dietary supplement improves walking distance and lipids after myocardial infarction. An open-label randomized clinical trial

Lilith Arevström, Cecilia Bergh, Rikard Landberg, Huaxing Wu, Ana Maria Rodriguez Mateos, Micael Waldenborg, Anders Magnuson, Stepháne Blanc, Ole Fröberta

Nutritional Sciences

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Abstract

Bilberries, Vaccinium myrtillus, have a high content of phenolic compounds including anthocyanins, which could provide cardiometabolic health benefits following acute myocardial infarction (AMI). We hypothesized that standard medical therapy supplemented with freeze-dried bilberry after AMI would have a more beneficial effect on cardiovascular risk markers and exercise capacity than medical therapy alone. Patients were allocated in a 1:1 ratio within 24 hours of percutaneous coronary intervention (PCI) in a 8 week trial to either V. myrtillus powder (40 g per day, equivalent to 480 g fresh bilberries) and standard medical therapy, or to a control group receiving standard medical therapy alone. High sensitivity C-reactive protein (hs-CRP) and exercise capacity measured with the 6-minute walk test (6MWT) were primary biochemical and clinical endpoints, respectively. Fifty subjects completed the study. No statistically significant difference in hs-CRP was detected between groups. The mean 6MWT distance increased significantly more in the bilberry group compared to the control group, mean difference 38 m at follow-up (95% CI 14-62, p=0.003). Ex vivo oxidized LDL was significantly lowered in the bilberry group compared to control, geometric mean ratio 0.80 (95% CI 0.66-0.96, p=0.017), while total cholesterol and LDL cholesterol did not differ significantly between groups. Anthocyanin derived metabolites in blood increased significantly in the bilberry group during the intervention and were different after 8 weeks between the bilberry group and control. Findings in the present study suggest that bilberries may have clinically relevant beneficial effects following AMI, a larger, double-blind clinical trial is warranted to confirm this.

Original language	English
Pages (from-to)	13-22
Journal	NUTRITION RESEARCH
Volume	62
Early online date	17 Nov 2018
DOIs	https://doi.org/10.1016/j.nutres.2018.11.008
Publication status	E-pub ahead of print - 17 Nov 2018

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Arevström, L., Bergh, C., Landberg, R., Wu, H., Rodriguez Mateos, A. M., Waldenborg, M., Magnuson, A., Blanc, S., & Fröberta, O. (2018). Freeze-dried bilberry (Vaccinium myrtillus) dietary supplement improves walking distance and lipids after myocardial infarction. An open-label randomized clinical trial. NUTRITION RESEARCH, 62, 13-22. Advance online publication. https://doi.org/10.1016/j.nutres.2018.11.008

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title = "Freeze-dried bilberry (Vaccinium myrtillus) dietary supplement improves walking distance and lipids after myocardial infarction. An open-label randomized clinical trial",

abstract = "Bilberries, Vaccinium myrtillus, have a high content of phenolic compounds including anthocyanins, which could provide cardiometabolic health benefits following acute myocardial infarction (AMI). We hypothesized that standard medical therapy supplemented with freeze-dried bilberry after AMI would have a more beneficial effect on cardiovascular risk markers and exercise capacity than medical therapy alone. Patients were allocated in a 1:1 ratio within 24 hours of percutaneous coronary intervention (PCI) in a 8 week trial to either V. myrtillus powder (40 g per day, equivalent to 480 g fresh bilberries) and standard medical therapy, or to a control group receiving standard medical therapy alone. High sensitivity C-reactive protein (hs-CRP) and exercise capacity measured with the 6-minute walk test (6MWT) were primary biochemical and clinical endpoints, respectively. Fifty subjects completed the study. No statistically significant difference in hs-CRP was detected between groups. The mean 6MWT distance increased significantly more in the bilberry group compared to the control group, mean difference 38 m at follow-up (95% CI 14-62, p=0.003). Ex vivo oxidized LDL was significantly lowered in the bilberry group compared to control, geometric mean ratio 0.80 (95% CI 0.66-0.96, p=0.017), while total cholesterol and LDL cholesterol did not differ significantly between groups. Anthocyanin derived metabolites in blood increased significantly in the bilberry group during the intervention and were different after 8 weeks between the bilberry group and control. Findings in the present study suggest that bilberries may have clinically relevant beneficial effects following AMI, a larger, double-blind clinical trial is warranted to confirm this.",

author = "Lilith Arevstr{\"o}m and Cecilia Bergh and Rikard Landberg and Huaxing Wu and {Rodriguez Mateos}, {Ana Maria} and Micael Waldenborg and Anders Magnuson and Steph{\'a}ne Blanc and Ole Fr{\"o}berta",

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Arevström, L, Bergh, C, Landberg, R, Wu, H, Rodriguez Mateos, AM, Waldenborg, M, Magnuson, A, Blanc, S & Fröberta, O 2018, 'Freeze-dried bilberry (Vaccinium myrtillus) dietary supplement improves walking distance and lipids after myocardial infarction. An open-label randomized clinical trial', NUTRITION RESEARCH, vol. 62, pp. 13-22. https://doi.org/10.1016/j.nutres.2018.11.008

TY - JOUR

T1 - Freeze-dried bilberry (Vaccinium myrtillus) dietary supplement improves walking distance and lipids after myocardial infarction. An open-label randomized clinical trial

AU - Arevström, Lilith

AU - Bergh, Cecilia

AU - Landberg, Rikard

AU - Wu, Huaxing

AU - Rodriguez Mateos, Ana Maria

AU - Waldenborg, Micael

AU - Magnuson, Anders

AU - Blanc, Stepháne

AU - Fröberta, Ole

PY - 2018/11/17

Y1 - 2018/11/17

N2 - Bilberries, Vaccinium myrtillus, have a high content of phenolic compounds including anthocyanins, which could provide cardiometabolic health benefits following acute myocardial infarction (AMI). We hypothesized that standard medical therapy supplemented with freeze-dried bilberry after AMI would have a more beneficial effect on cardiovascular risk markers and exercise capacity than medical therapy alone. Patients were allocated in a 1:1 ratio within 24 hours of percutaneous coronary intervention (PCI) in a 8 week trial to either V. myrtillus powder (40 g per day, equivalent to 480 g fresh bilberries) and standard medical therapy, or to a control group receiving standard medical therapy alone. High sensitivity C-reactive protein (hs-CRP) and exercise capacity measured with the 6-minute walk test (6MWT) were primary biochemical and clinical endpoints, respectively. Fifty subjects completed the study. No statistically significant difference in hs-CRP was detected between groups. The mean 6MWT distance increased significantly more in the bilberry group compared to the control group, mean difference 38 m at follow-up (95% CI 14-62, p=0.003). Ex vivo oxidized LDL was significantly lowered in the bilberry group compared to control, geometric mean ratio 0.80 (95% CI 0.66-0.96, p=0.017), while total cholesterol and LDL cholesterol did not differ significantly between groups. Anthocyanin derived metabolites in blood increased significantly in the bilberry group during the intervention and were different after 8 weeks between the bilberry group and control. Findings in the present study suggest that bilberries may have clinically relevant beneficial effects following AMI, a larger, double-blind clinical trial is warranted to confirm this.

AB - Bilberries, Vaccinium myrtillus, have a high content of phenolic compounds including anthocyanins, which could provide cardiometabolic health benefits following acute myocardial infarction (AMI). We hypothesized that standard medical therapy supplemented with freeze-dried bilberry after AMI would have a more beneficial effect on cardiovascular risk markers and exercise capacity than medical therapy alone. Patients were allocated in a 1:1 ratio within 24 hours of percutaneous coronary intervention (PCI) in a 8 week trial to either V. myrtillus powder (40 g per day, equivalent to 480 g fresh bilberries) and standard medical therapy, or to a control group receiving standard medical therapy alone. High sensitivity C-reactive protein (hs-CRP) and exercise capacity measured with the 6-minute walk test (6MWT) were primary biochemical and clinical endpoints, respectively. Fifty subjects completed the study. No statistically significant difference in hs-CRP was detected between groups. The mean 6MWT distance increased significantly more in the bilberry group compared to the control group, mean difference 38 m at follow-up (95% CI 14-62, p=0.003). Ex vivo oxidized LDL was significantly lowered in the bilberry group compared to control, geometric mean ratio 0.80 (95% CI 0.66-0.96, p=0.017), while total cholesterol and LDL cholesterol did not differ significantly between groups. Anthocyanin derived metabolites in blood increased significantly in the bilberry group during the intervention and were different after 8 weeks between the bilberry group and control. Findings in the present study suggest that bilberries may have clinically relevant beneficial effects following AMI, a larger, double-blind clinical trial is warranted to confirm this.

U2 - 10.1016/j.nutres.2018.11.008

DO - 10.1016/j.nutres.2018.11.008

M3 - Article

SN - 0271-5317

VL - 62

SP - 13

EP - 22

JO - NUTRITION RESEARCH

JF - NUTRITION RESEARCH

ER -

Freeze-dried bilberry (Vaccinium myrtillus) dietary supplement improves walking distance and lipids after myocardial infarction. An open-label randomized clinical trial

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