Freeze-fracture analysis of plasma membranes in Duchenne muscular dystrophy. A study using cultured skin fibroblasts

G. E. Jones; N. J. Severs; J. A. Witkowski

doi:10.1016/0022-510X(83)90216-2

Freeze-fracture analysis of plasma membranes in Duchenne muscular dystrophy. A study using cultured skin fibroblasts

G. E. Jones^*, N. J. Severs, J. A. Witkowski

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Quantitative freeze-fracture studies of the numercial density and distribution of intramembrane particles (IMP) were carried out on the plasma membrane of cultured skin fibroblasts from 4 patients with Duchenne muscular dystrophy and 3 normal controls. Analysis of P and E fracture faces of the fibroblast plasma membrane failed to show any significant differences in either IMP density or distribution between normal and dystrophic specimens. In contrast to previous reports, our results indicate that an altered IMP density is not a characteristic feature of the dystrophic cell membrane.

Original language	English
Pages (from-to)	185-193
Number of pages	9
Journal	Journal of the Neurological Sciences
Volume	58
Issue number	2
DOIs	https://doi.org/10.1016/0022-510X(83)90216-2
Publication status	Published - 1 Jan 1983

Access to Document

10.1016/0022-510X(83)90216-2

Cite this

@article{7353056524084a3dadd82667964dae70,

title = "Freeze-fracture analysis of plasma membranes in Duchenne muscular dystrophy. A study using cultured skin fibroblasts",

abstract = "Quantitative freeze-fracture studies of the numercial density and distribution of intramembrane particles (IMP) were carried out on the plasma membrane of cultured skin fibroblasts from 4 patients with Duchenne muscular dystrophy and 3 normal controls. Analysis of P and E fracture faces of the fibroblast plasma membrane failed to show any significant differences in either IMP density or distribution between normal and dystrophic specimens. In contrast to previous reports, our results indicate that an altered IMP density is not a characteristic feature of the dystrophic cell membrane.",

author = "Jones, {G. E.} and Severs, {N. J.} and Witkowski, {J. A.}",

year = "1983",

month = jan,

day = "1",

doi = "10.1016/0022-510X(83)90216-2",

language = "English",

volume = "58",

pages = "185--193",

journal = "Journal of the Neurological Sciences",

issn = "0022-510X",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Freeze-fracture analysis of plasma membranes in Duchenne muscular dystrophy. A study using cultured skin fibroblasts

AU - Jones, G. E.

AU - Severs, N. J.

AU - Witkowski, J. A.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - Quantitative freeze-fracture studies of the numercial density and distribution of intramembrane particles (IMP) were carried out on the plasma membrane of cultured skin fibroblasts from 4 patients with Duchenne muscular dystrophy and 3 normal controls. Analysis of P and E fracture faces of the fibroblast plasma membrane failed to show any significant differences in either IMP density or distribution between normal and dystrophic specimens. In contrast to previous reports, our results indicate that an altered IMP density is not a characteristic feature of the dystrophic cell membrane.

AB - Quantitative freeze-fracture studies of the numercial density and distribution of intramembrane particles (IMP) were carried out on the plasma membrane of cultured skin fibroblasts from 4 patients with Duchenne muscular dystrophy and 3 normal controls. Analysis of P and E fracture faces of the fibroblast plasma membrane failed to show any significant differences in either IMP density or distribution between normal and dystrophic specimens. In contrast to previous reports, our results indicate that an altered IMP density is not a characteristic feature of the dystrophic cell membrane.

UR - http://www.scopus.com/inward/record.url?scp=0020685080&partnerID=8YFLogxK

U2 - 10.1016/0022-510X(83)90216-2

DO - 10.1016/0022-510X(83)90216-2

M3 - Article

C2 - 6300339

AN - SCOPUS:0020685080

SN - 0022-510X

VL - 58

SP - 185

EP - 193

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

IS - 2

ER -

Freeze-fracture analysis of plasma membranes in Duchenne muscular dystrophy. A study using cultured skin fibroblasts

Abstract

Access to Document

Other files and links

Fingerprint

Cite this