From allostatic load to allostatic state—an endogenous sympathetic strategy to deal with chronic anxiety and stress?

Enrico Ullmann; Seth W. Perry; Julio Licinio; Ma Li Wong; Eliyahu Dremencov; Evgenii L. Zavjalov; Oleg B. Shevelev; Nikita V. Khotskin; Galina V. Koncevaya; Anna S. Khotshkina; Mikhail P. Moshkin; Maxim S. Lapshin; Maria V. Komelkova; Inna V. Feklicheva; Olga B. Tseilikman; Olga P. Cherkasova; Kamaldeep S. Bhui; Edgar Jones; Clemens Kirschbaum; Stefan R. Bornstein; Vadim Tseilikman

doi:10.3389/fnbeh.2019.00047

From allostatic load to allostatic state—an endogenous sympathetic strategy to deal with chronic anxiety and stress?

Enrico Ullmann^*, Seth W. Perry, Julio Licinio, Ma Li Wong, Eliyahu Dremencov, Evgenii L. Zavjalov, Oleg B. Shevelev, Nikita V. Khotskin, Galina V. Koncevaya, Anna S. Khotshkina, Mikhail P. Moshkin, Maxim S. Lapshin, Maria V. Komelkova, Inna V. Feklicheva, Olga B. Tseilikman, Olga P. Cherkasova, Kamaldeep S. Bhui, Edgar Jones, Clemens Kirschbaum, Stefan R. BornsteinVadim Tseilikman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The concepts of allostatic load and overload, i. e., a dramatic increase in the allostatic load that predisposes to disease, have been extensively described in the literature. Here, we show that rats engaging in active offensive response (AOR) behavioral strategies to chronic predator scent stress (PSS) display less anxiety behavior and lower plasma cortisol levels vs. rats engaging in passive defensive response (PDR) behavioral strategies to chronic PSS. In the same chronic PSS paradigm, AOR rats also have higher lactate and lower glutamate levels in amygdala but not in control-region hippocampus vs. PDR rats. The implications of these findings for regulation of allostatic and stress responses, and post-traumatic stress disorder (PTSD) are discussed.

Original language	English
Article number	47
Journal	Frontiers in Behavioral Neuroscience
Volume	13
DOIs	https://doi.org/10.3389/fnbeh.2019.00047
Publication status	Published - 30 Jan 2019

Keywords

Allostasis/homeostasis
Behavior
Glutamate
PTSD (post-traumatic stress disorder)
Stress-diseases

Access to Document

10.3389/fnbeh.2019.00047

Cite this

Ullmann, E., Perry, S. W., Licinio, J., Wong, M. L., Dremencov, E., Zavjalov, E. L., Shevelev, O. B., Khotskin, N. V., Koncevaya, G. V., Khotshkina, A. S., Moshkin, M. P., Lapshin, M. S., Komelkova, M. V., Feklicheva, I. V., Tseilikman, O. B., Cherkasova, O. P., Bhui, K. S., Jones, E., Kirschbaum, C., ... Tseilikman, V. (2019). From allostatic load to allostatic state—an endogenous sympathetic strategy to deal with chronic anxiety and stress? Frontiers in Behavioral Neuroscience, 13, Article 47. https://doi.org/10.3389/fnbeh.2019.00047

@article{c60e475b1d2443af860115602618c139,

title = "From allostatic load to allostatic state—an endogenous sympathetic strategy to deal with chronic anxiety and stress?",

abstract = "The concepts of allostatic load and overload, i. e., a dramatic increase in the allostatic load that predisposes to disease, have been extensively described in the literature. Here, we show that rats engaging in active offensive response (AOR) behavioral strategies to chronic predator scent stress (PSS) display less anxiety behavior and lower plasma cortisol levels vs. rats engaging in passive defensive response (PDR) behavioral strategies to chronic PSS. In the same chronic PSS paradigm, AOR rats also have higher lactate and lower glutamate levels in amygdala but not in control-region hippocampus vs. PDR rats. The implications of these findings for regulation of allostatic and stress responses, and post-traumatic stress disorder (PTSD) are discussed.",

keywords = "Allostasis/homeostasis, Behavior, Glutamate, PTSD (post-traumatic stress disorder), Stress-diseases",

author = "Enrico Ullmann and Perry, {Seth W.} and Julio Licinio and Wong, {Ma Li} and Eliyahu Dremencov and Zavjalov, {Evgenii L.} and Shevelev, {Oleg B.} and Khotskin, {Nikita V.} and Koncevaya, {Galina V.} and Khotshkina, {Anna S.} and Moshkin, {Mikhail P.} and Lapshin, {Maxim S.} and Komelkova, {Maria V.} and Feklicheva, {Inna V.} and Tseilikman, {Olga B.} and Cherkasova, {Olga P.} and Bhui, {Kamaldeep S.} and Edgar Jones and Clemens Kirschbaum and Bornstein, {Stefan R.} and Vadim Tseilikman",

year = "2019",

month = jan,

day = "30",

doi = "10.3389/fnbeh.2019.00047",

language = "English",

volume = "13",

journal = "Frontiers in Behavioral Neuroscience",

issn = "1662-5153",