From Computation to the First-Person: Auditory-Verbal Hallucinations and Delusions of Thought Interference in Schizophrenia-Spectrum Psychoses

Clara S. Humpston; Rick A. Adams; David Benrimoh; Matthew R. Broome; Philip R Corlett; Philip Gerrans; Guillermo Horga; Thomas Parr; Elizabeth Pienkos; Albert R Powers III; Andrea Raballo; Cherise Rosen; David E. J. Linden

doi:10.1093/schbul/sby073

From Computation to the First-Person: Auditory-Verbal Hallucinations and Delusions of Thought Interference in Schizophrenia-Spectrum Psychoses

Clara S. Humpston, Rick A. Adams, David Benrimoh, Matthew R. Broome, Philip R Corlett, Philip Gerrans, Guillermo Horga, Thomas Parr, Elizabeth Pienkos, Albert R Powers III, Andrea Raballo, Cherise Rosen, David E. J. Linden

Psychological Medicine

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Schizophrenia-spectrum psychoses are highly complex and heterogeneous disorders that necessitate multiple lines of scientific inquiry and levels of explanation. In recent years, both computational and phenomenological approaches to the understanding of mental illness have received much interest, and significant progress has been made in both fields. However, there has been relatively little progress bridging investigations in these seemingly disparate fields. In this conceptual review and collaborative project from the 4th Meeting of the International Consortium on Hallucination Research, we aim to facilitate the beginning of such dialogue between fields and put forward the argument that computational psychiatry and phenomenology can in fact inform each other, rather than being viewed as isolated or even incompatible approaches. We begin with an overview of phenomenological observations on the interrelationships between auditory-verbal hallucinations (AVH) and delusional thoughts in general, before moving on to review several theoretical frameworks and empirical findings in the computational modeling of AVH. We then relate the computational models to the phenomenological accounts, with a special focus on AVH and delusions that involve the senses of agency and ownership of thought (delusions of thought interference). Finally, we offer some tentative directions for future research, emphasizing the importance of a mutual understanding between separate lines of inquiry.

Original language	English
Pages (from-to)	S56-S66
Journal	Schizophrenia Bulletin
Volume	45
Issue number	1
DOIs	https://doi.org/10.1093/schbul/sby073
Publication status	Published - 1 Feb 2019

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10.1093/schbul/sby073Licence: CC BY

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Humpston, C. S., Adams, R. A., Benrimoh, D., Broome, M. R., Corlett, P. R., Gerrans, P., Horga, G., Parr, T., Pienkos, E., Powers III, A. R., Raballo, A., Rosen, C., & Linden, D. E. J. (2019). From Computation to the First-Person: Auditory-Verbal Hallucinations and Delusions of Thought Interference in Schizophrenia-Spectrum Psychoses. Schizophrenia Bulletin, 45(1), S56-S66. https://doi.org/10.1093/schbul/sby073

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abstract = "Schizophrenia-spectrum psychoses are highly complex and heterogeneous disorders that necessitate multiple lines of scientific inquiry and levels of explanation. In recent years, both computational and phenomenological approaches to the understanding of mental illness have received much interest, and significant progress has been made in both fields. However, there has been relatively little progress bridging investigations in these seemingly disparate fields. In this conceptual review and collaborative project from the 4th Meeting of the International Consortium on Hallucination Research, we aim to facilitate the beginning of such dialogue between fields and put forward the argument that computational psychiatry and phenomenology can in fact inform each other, rather than being viewed as isolated or even incompatible approaches. We begin with an overview of phenomenological observations on the interrelationships between auditory-verbal hallucinations (AVH) and delusional thoughts in general, before moving on to review several theoretical frameworks and empirical findings in the computational modeling of AVH. We then relate the computational models to the phenomenological accounts, with a special focus on AVH and delusions that involve the senses of agency and ownership of thought (delusions of thought interference). Finally, we offer some tentative directions for future research, emphasizing the importance of a mutual understanding between separate lines of inquiry.",

author = "Humpston, {Clara S.} and Adams, {Rick A.} and David Benrimoh and Broome, {Matthew R.} and Corlett, {Philip R} and Philip Gerrans and Guillermo Horga and Thomas Parr and Elizabeth Pienkos and {Powers III}, {Albert R} and Andrea Raballo and Cherise Rosen and Linden, {David E. J.}",

year = "2019",

month = feb,

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doi = "10.1093/schbul/sby073",

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Humpston, CS, Adams, RA, Benrimoh, D, Broome, MR, Corlett, PR, Gerrans, P, Horga, G, Parr, T, Pienkos, E, Powers III, AR, Raballo, A, Rosen, C & Linden, DEJ 2019, 'From Computation to the First-Person: Auditory-Verbal Hallucinations and Delusions of Thought Interference in Schizophrenia-Spectrum Psychoses', Schizophrenia Bulletin, vol. 45, no. 1, pp. S56-S66. https://doi.org/10.1093/schbul/sby073

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AU - Broome, Matthew R.

AU - Corlett, Philip R

AU - Gerrans, Philip

AU - Horga, Guillermo

AU - Parr, Thomas

AU - Pienkos, Elizabeth

AU - Powers III, Albert R

AU - Raballo, Andrea

AU - Rosen, Cherise

AU - Linden, David E. J.

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N2 - Schizophrenia-spectrum psychoses are highly complex and heterogeneous disorders that necessitate multiple lines of scientific inquiry and levels of explanation. In recent years, both computational and phenomenological approaches to the understanding of mental illness have received much interest, and significant progress has been made in both fields. However, there has been relatively little progress bridging investigations in these seemingly disparate fields. In this conceptual review and collaborative project from the 4th Meeting of the International Consortium on Hallucination Research, we aim to facilitate the beginning of such dialogue between fields and put forward the argument that computational psychiatry and phenomenology can in fact inform each other, rather than being viewed as isolated or even incompatible approaches. We begin with an overview of phenomenological observations on the interrelationships between auditory-verbal hallucinations (AVH) and delusional thoughts in general, before moving on to review several theoretical frameworks and empirical findings in the computational modeling of AVH. We then relate the computational models to the phenomenological accounts, with a special focus on AVH and delusions that involve the senses of agency and ownership of thought (delusions of thought interference). Finally, we offer some tentative directions for future research, emphasizing the importance of a mutual understanding between separate lines of inquiry.

AB - Schizophrenia-spectrum psychoses are highly complex and heterogeneous disorders that necessitate multiple lines of scientific inquiry and levels of explanation. In recent years, both computational and phenomenological approaches to the understanding of mental illness have received much interest, and significant progress has been made in both fields. However, there has been relatively little progress bridging investigations in these seemingly disparate fields. In this conceptual review and collaborative project from the 4th Meeting of the International Consortium on Hallucination Research, we aim to facilitate the beginning of such dialogue between fields and put forward the argument that computational psychiatry and phenomenology can in fact inform each other, rather than being viewed as isolated or even incompatible approaches. We begin with an overview of phenomenological observations on the interrelationships between auditory-verbal hallucinations (AVH) and delusional thoughts in general, before moving on to review several theoretical frameworks and empirical findings in the computational modeling of AVH. We then relate the computational models to the phenomenological accounts, with a special focus on AVH and delusions that involve the senses of agency and ownership of thought (delusions of thought interference). Finally, we offer some tentative directions for future research, emphasizing the importance of a mutual understanding between separate lines of inquiry.

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From Computation to the First-Person: Auditory-Verbal Hallucinations and Delusions of Thought Interference in Schizophrenia-Spectrum Psychoses

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