TY - JOUR
T1 - From dysthymia to treatment-resistant depression
T2 - evolution of a psychopathological construct
AU - Ventriglio, Antonio
AU - Bhugra, Dinesh
AU - Sampogna, Gaia
AU - Luciano, Mario
AU - De Berardis, Domenico
AU - Sani, Gabriele
AU - Fiorillo, Andrea
PY - 2020/8/17
Y1 - 2020/8/17
N2 - Dysthymia is a psychopathological construct historically described and often reconsidered through the centuries. Its first description is dated back to 400 b.C., when Hippocrates proposed his theory about the ‘black bile’ and the melancholic temperament. The concept of dysthymia (dys-, ‘ill’, thymia-, ‘emotions’) has been largely elaborated in the XIX and XX centuries by Burton, Cullen, Schneider, Kretschmer, Akiskal and other authors, and recently re-formulated in the various editions of the modern Diagnostic and Statistical Manual of Mental Disorders under different diagnostic labels: neurotic depression, dysthymic disorder, persistent depressive disorder. Beyond the nosology, dysthymia issues some other challenges, including the need for further research to characterise the peculiar pathophysiological framework of this syndrome (compared with major depressive disorder) and to better define evidences about tailored-treatment options and their effectiveness.
AB - Dysthymia is a psychopathological construct historically described and often reconsidered through the centuries. Its first description is dated back to 400 b.C., when Hippocrates proposed his theory about the ‘black bile’ and the melancholic temperament. The concept of dysthymia (dys-, ‘ill’, thymia-, ‘emotions’) has been largely elaborated in the XIX and XX centuries by Burton, Cullen, Schneider, Kretschmer, Akiskal and other authors, and recently re-formulated in the various editions of the modern Diagnostic and Statistical Manual of Mental Disorders under different diagnostic labels: neurotic depression, dysthymic disorder, persistent depressive disorder. Beyond the nosology, dysthymia issues some other challenges, including the need for further research to characterise the peculiar pathophysiological framework of this syndrome (compared with major depressive disorder) and to better define evidences about tailored-treatment options and their effectiveness.
KW - Dysthymia
KW - dysthymic disorder
KW - persistent depressive disorder
KW - treatment- resistant depression
UR - http://www.scopus.com/inward/record.url?scp=85085505196&partnerID=8YFLogxK
U2 - 10.1080/09540261.2020.1765517
DO - 10.1080/09540261.2020.1765517
M3 - Review article
C2 - 32436408
AN - SCOPUS:85085505196
SN - 0954-0261
VL - 32
SP - 471
EP - 476
JO - International Review of Psychiatry
JF - International Review of Psychiatry
IS - 5-6
ER -