TY - JOUR
T1 - From Neurotransmitters to Networks
T2 - Transcending Organisational Hierarchies with Molecular-informed Functional Imaging
AU - Lawn, Timothy
AU - Howard, Matthew A
AU - Turkheimer, Federico
AU - Misic, Bratislav
AU - Deco, Gustavo
AU - Martins, Daniel
AU - Dipasquale, Ottavia
N1 - Funding Information:
TL is in receipt of a PhD studentship funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London. MAH, DM, and OD are supported by the NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London. MAH is also supported by the Medical Research Council (MR/N026969/1). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care.
Funding Information:
TL is in receipt of a PhD studentship funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London . MAH, DM, and OD are supported by the NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. MAH is also supported by the Medical Research Council ( MR/N026969/1 ). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care.
Publisher Copyright:
© 2023 The Authors
PY - 2023/7
Y1 - 2023/7
N2 - The human brain exhibits complex interactions across micro, meso-, and macro-scale organisational principles. Recent synergistic multi-modal approaches have begun to link micro-scale information to systems level dynamics, transcending organisational hierarchies and offering novel perspectives into the brain's function and dysfunction. Specifically, the distribution of micro-scale properties (such as receptor density or gene expression) can be mapped onto macro-scale measures from functional MRI to provide novel neurobiological insights. Methodological approaches to enrich functional imaging analyses with molecular information are rapidly evolving, with several streams of research having developed relatively independently, each offering unique potential to explore the trans-hierarchical functioning of the brain. Here, we address the three principal streams of research - spatial correlation, molecular-enriched network, and in-silico whole brain modelling analyses - to provide a critical overview of the different sources of molecular information, how this information can be utilised within analyses of fMRI data, the merits and pitfalls of each methodology, and, through the use of key examples, highlight their promise to shed new light on key domains of neuroscientific inquiry.
AB - The human brain exhibits complex interactions across micro, meso-, and macro-scale organisational principles. Recent synergistic multi-modal approaches have begun to link micro-scale information to systems level dynamics, transcending organisational hierarchies and offering novel perspectives into the brain's function and dysfunction. Specifically, the distribution of micro-scale properties (such as receptor density or gene expression) can be mapped onto macro-scale measures from functional MRI to provide novel neurobiological insights. Methodological approaches to enrich functional imaging analyses with molecular information are rapidly evolving, with several streams of research having developed relatively independently, each offering unique potential to explore the trans-hierarchical functioning of the brain. Here, we address the three principal streams of research - spatial correlation, molecular-enriched network, and in-silico whole brain modelling analyses - to provide a critical overview of the different sources of molecular information, how this information can be utilised within analyses of fMRI data, the merits and pitfalls of each methodology, and, through the use of key examples, highlight their promise to shed new light on key domains of neuroscientific inquiry.
UR - http://www.scopus.com/inward/record.url?scp=85153591242&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2023.105193
DO - 10.1016/j.neubiorev.2023.105193
M3 - Review article
C2 - 37086932
SN - 0149-7634
VL - 150
SP - 105193
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
M1 - 105193
ER -