TY - JOUR
T1 - From Speech Illusions to Onset of Psychotic Disorder
T2 - Applying Network Analysis to an Experimental Measure of Aberrant Experiences
AU - EU-GEI High Risk Study
AU - Boyette, Lindy Lou
AU - Isvoranu, Adela Maria
AU - Schirmbeck, Frederike
AU - Velthorst, Eva
AU - Simons, Claudia J.P.
AU - Barrantes-Vidal, Neus
AU - Bressan, Rodrigo
AU - Kempton, Matthew J.
AU - Krebs, Marie Odile
AU - Mcguire, Philip
AU - Nelson, Barnaby
AU - Nordentoft, Merete
AU - Riecher-Rössler, Anita
AU - Ruhrmann, Stephan
AU - Rutten, Bart P.
AU - Sachs, Gabriele
AU - Valmaggia, Lucia R.
AU - Van Der Gaag, Mark
AU - Borsboom, Denny
AU - De Haan, Lieuwe
AU - Van Os, Jim
AU - Calem, Maria
AU - Tognin, Stefania
AU - Modinos, Gemma
AU - Kraan, Tamar C.
AU - Van Dam, Daniella S.
AU - Burger, Nadine
AU - Nelson, Barnaby
AU - Mcgorry, Patrick
AU - Amminger, G. Paul
AU - Pantelis, Christos
AU - Politis, Athena
AU - Goodall, Joanne
AU - Riecher-Rössler, Anita
AU - Borgwardt, Stefan
AU - Studerus, Erich
AU - Bressan, Rodrigo
AU - Gadelha, Ary
AU - Brietzke, Elisa
AU - Asevedo, Graccielle
AU - Asevedo, Elson
AU - Zugman, Andre
AU - Barrantes-Vidal, Neus
AU - Domínguez-Martínez, Tecelli
AU - Cristóbal-Narváez, Paula
AU - Kwapil, Thomas R.
AU - Monsonet, Manel
AU - Hinojosa, Lídia
AU - Kazes, Mathilde
AU - Daban, Claire
N1 - Publisher Copyright:
© The Author(s) 2020.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Aberrant perceptional experiences are a potential early marker of psychosis development. Earlier studies have found experimentally assessed speech illusions to be associated with positive symptoms in patients with psychotic disorders, but findings for attenuated symptoms in individuals without psychotic disorders have been inconsistent. Also, the role of affect is unclear. The aim of this study was to use the network approach to investigate how speech illusions relate to individual symptoms and onset of a psychotic disorder. We estimated a network model based on data from 289 Clinical High-Risk (CHR) subjects, participating in the EU-GEI project. The network structure depicts statistical associations between (affective and all) speech illusions, cross-sectional individual attenuated positive and affective symptoms, and transition to psychotic disorder after conditioning on all other variables in the network. Speech illusions were assessed with the White Noise Task, symptoms with the BPRS and transition during 24-month follow-up with the CAARMS. Affective, not all, speech illusions were found to be directly, albeit weakly, associated with hallucinatory experiences. Hallucinatory experiences, in turn, were associated with delusional ideation. Bizarre behavior was the only symptom in the network steadily predictive of transition. Affective symptoms were highly interrelated with depression showing the highest overall strength of connections to and predictability by other symptoms. Both speech illusions and transition showed low overall predictability by symptoms. Our findings suggest that experimentally assessed speech illusions are not a mere consequence of psychotic symptoms or disorder, but that their single assessment is likely not useful for assessing transition risk.
AB - Aberrant perceptional experiences are a potential early marker of psychosis development. Earlier studies have found experimentally assessed speech illusions to be associated with positive symptoms in patients with psychotic disorders, but findings for attenuated symptoms in individuals without psychotic disorders have been inconsistent. Also, the role of affect is unclear. The aim of this study was to use the network approach to investigate how speech illusions relate to individual symptoms and onset of a psychotic disorder. We estimated a network model based on data from 289 Clinical High-Risk (CHR) subjects, participating in the EU-GEI project. The network structure depicts statistical associations between (affective and all) speech illusions, cross-sectional individual attenuated positive and affective symptoms, and transition to psychotic disorder after conditioning on all other variables in the network. Speech illusions were assessed with the White Noise Task, symptoms with the BPRS and transition during 24-month follow-up with the CAARMS. Affective, not all, speech illusions were found to be directly, albeit weakly, associated with hallucinatory experiences. Hallucinatory experiences, in turn, were associated with delusional ideation. Bizarre behavior was the only symptom in the network steadily predictive of transition. Affective symptoms were highly interrelated with depression showing the highest overall strength of connections to and predictability by other symptoms. Both speech illusions and transition showed low overall predictability by symptoms. Our findings suggest that experimentally assessed speech illusions are not a mere consequence of psychotic symptoms or disorder, but that their single assessment is likely not useful for assessing transition risk.
KW - hallucinations
KW - hallucinatory experiences
KW - network approach
KW - psychosis/transition/high risk
UR - http://www.scopus.com/inward/record.url?scp=85104273369&partnerID=8YFLogxK
U2 - 10.1093/schizbullopen/sgaa025
DO - 10.1093/schizbullopen/sgaa025
M3 - Article
AN - SCOPUS:85104273369
SN - 2632-7899
VL - 1
JO - Schizophrenia Bulletin Open
JF - Schizophrenia Bulletin Open
IS - 1
M1 - sgaa025
ER -