Frontal cortex functioning in the infant broader autism phenotype

TY - JOUR

T1 - Frontal cortex functioning in the infant broader autism phenotype

AU - Holmboe, Karla

AU - Elsabbagh, Mayada

AU - Volein, Agnes

AU - Tucker, Leslie A.

AU - Baron-Cohen, Simon

AU - Bolton, Patrick

AU - Charman, Tony

AU - Johnson, Mark H.

PY - 2010/12

Y1 - 2010/12

N2 - Atypical attention has been proposed as a marker of the broader autism phenotype In the present study we investigated this and the related process of Inhibitory control at the youngest possible age through the study of infant siblings of children with an autism spectrum disorder (Sibs-ASD) Both attention and inhibition have been related to the frontal cortex of the brain Nine- to ten-month-old Sibs-ASD and low-risk control infants completed the Freeze-Frame task in which infants are encouraged to inhibit looks to peripherally presented distractors whilst looking at a central animation The attractiveness of the central stimulus is varied in order to investigate the selectivity of Infants responses In line with previous studies It was found that a subset of Sibs-ASD infants had difficulty disengaging attention from a central stimulus in order to orient to a peripheral stimulus The Sibs-ASD group also showed less Selective Inhibition than controls However Sibs-ASD infants did demonstrate Selective Inhibitory Learning These results provide preliminary evidence for atypical frontal cortex functioning in the infant broader autism phenotype.

AB - Atypical attention has been proposed as a marker of the broader autism phenotype In the present study we investigated this and the related process of Inhibitory control at the youngest possible age through the study of infant siblings of children with an autism spectrum disorder (Sibs-ASD) Both attention and inhibition have been related to the frontal cortex of the brain Nine- to ten-month-old Sibs-ASD and low-risk control infants completed the Freeze-Frame task in which infants are encouraged to inhibit looks to peripherally presented distractors whilst looking at a central animation The attractiveness of the central stimulus is varied in order to investigate the selectivity of Infants responses In line with previous studies It was found that a subset of Sibs-ASD infants had difficulty disengaging attention from a central stimulus in order to orient to a peripheral stimulus The Sibs-ASD group also showed less Selective Inhibition than controls However Sibs-ASD infants did demonstrate Selective Inhibitory Learning These results provide preliminary evidence for atypical frontal cortex functioning in the infant broader autism phenotype.

U2 - 10.1016/j.infbeh.2010.05.004

DO - 10.1016/j.infbeh.2010.05.004

M3 - Article

SN - 0163-6383

VL - 33

SP - 482

EP - 491

JO - Infant Behaviour and Development

JF - Infant Behaviour and Development

IS - 4

ER -