Fully integrated 3D high-resolution multicontrast abdominal PET-MR with high scan efficiency

Christoph Kolbitsch*, Radhouene Neji, Matthias Fenchel, Andrew Mallia, Paul Marsden, Tobias Schaeffter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)
157 Downloads (Pure)

Abstract

Purpose: To provide 3D multicontrast anatomical MR with high isotropic resolution and metabolic positron emission tomography (PET) images using a respiratory motion-compensated simultaneous PET-MR examination with high scan efficiency. Theory and Methods: Standard abdominal PET-MR examinations combine MR data obtained during multiple breath-holds with free-breathing PET acquisitions, limiting the achievable image resolution and potentially causing misalignment errors between breath-hold and free-breathing data. Here, a 3D free-breathing PET-MR acquisition is presented, yielding T1 and T2-weighted MR images with an isotropic resolution of 1.5mm3. In addition, nonrigid respiratory motion information and respiratory-resolved attenuation-correction maps are obtained without an increase in scan time. Motion information is used in motion-compensated image reconstructions to improve MR and PET image quality while shortening scan times. Results: The proposed approach was evaluated in 11 oncology patients and provided respiratory motion information with an accuracy of 1.3±0.1mm. Sharpness of anatomical features was increased by 19±13% compared with the uncorrected MR images in a 54±26% shorter scan time than a gated MR acquisition. The MR-based motion information improved uptake values (75±94%) and resolution (16±27%) of simultaneously acquired PET images. Conclusions: The proposed method provides motion-compensated 3D high-quality MR and PET images in a comprehensive and highly efficient examination.

Original languageEnglish
Pages (from-to)900-911
JournalMagnetic Resonance in Medicine
Volume79
Issue number2
Early online date14 May 2017
DOIs
Publication statusPublished - Feb 2018

Keywords

  • Abdominal imaging
  • Golden radial phase encoding
  • Respiratory motion compensation
  • Simultaneous PET-MR

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