Fully self-gated free-running 3D Cartesian cardiac CINE with isotropic whole-heart coverage in less than 2 min

TY - JOUR

T1 - Fully self-gated free-running 3D Cartesian cardiac CINE with isotropic whole-heart coverage in less than 2 min

AU - Küstner, Thomas

AU - Bustin, Aurelien

AU - Jaubert, Olivier

AU - Hajhosseiny, Reza

AU - Masci, Pier Giorgio

AU - Neji, Radhouene

AU - Botnar, René

AU - Prieto, Claudia

N1 - © 2020 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.

PY - 2021/1

Y1 - 2021/1

N2 - PURPOSE: To develop a novel fast water-selective free-breathing 3D Cartesian cardiac CINE scan with full self-navigation and isotropic whole-heart (WH) coverage.METHODS: A free-breathing 3D Cartesian cardiac CINE scan with a water-selective balanced steady-state free precession and a continuous (non-ECG-gated) variable-density Cartesian sampling with spiral profile ordering, out-inward sampling and acquisition-adaptive alternating tiny golden and golden angle increment between spiral arms is proposed. Data is retrospectively binned based on respiratory and cardiac self-navigation signals. A translational respiratory-motion-corrected and cardiac-motion-resolved image is reconstructed with a multi-bin patch-based low-rank reconstruction (MB-PROST) within about 15 min. A respiratory-motion-resolved approach is also investigated. The proposed 3D Cartesian cardiac CINE is acquired in sagittal orientation in 1 min 50 s for 1.9 mm3 isotropic WH coverage. Left ventricular (LV) function parameters and image quality derived from a blinded reading of the proposed 3D CINE framework are compared against conventional multi-slice 2D CINE imaging in 10 healthy subjects and 10 patients with suspected cardiovascular disease.RESULTS: The proposed framework provides free-breathing 3D cardiac CINE images with 1.9 mm3 spatial and about 45 ms temporal resolution in a short acquisition time (<2 min). LV function parameters derived from 3D CINE were in good agreement with 2D CINE (10 healthy subjects and 10 patients). Bias and confidence intervals were obtained for end-systolic volume, end-diastolic volume and ejection fraction of 0.1 ± 3.5 mL, -0.6 ± 8.2 mL and -0.1 ± 2.2%, respectively.CONCLUSION: The proposed framework enables isotropic 3D Cartesian cardiac CINE under free breathing for fast assessment of cardiac anatomy and function.

AB - PURPOSE: To develop a novel fast water-selective free-breathing 3D Cartesian cardiac CINE scan with full self-navigation and isotropic whole-heart (WH) coverage.METHODS: A free-breathing 3D Cartesian cardiac CINE scan with a water-selective balanced steady-state free precession and a continuous (non-ECG-gated) variable-density Cartesian sampling with spiral profile ordering, out-inward sampling and acquisition-adaptive alternating tiny golden and golden angle increment between spiral arms is proposed. Data is retrospectively binned based on respiratory and cardiac self-navigation signals. A translational respiratory-motion-corrected and cardiac-motion-resolved image is reconstructed with a multi-bin patch-based low-rank reconstruction (MB-PROST) within about 15 min. A respiratory-motion-resolved approach is also investigated. The proposed 3D Cartesian cardiac CINE is acquired in sagittal orientation in 1 min 50 s for 1.9 mm3 isotropic WH coverage. Left ventricular (LV) function parameters and image quality derived from a blinded reading of the proposed 3D CINE framework are compared against conventional multi-slice 2D CINE imaging in 10 healthy subjects and 10 patients with suspected cardiovascular disease.RESULTS: The proposed framework provides free-breathing 3D cardiac CINE images with 1.9 mm3 spatial and about 45 ms temporal resolution in a short acquisition time (<2 min). LV function parameters derived from 3D CINE were in good agreement with 2D CINE (10 healthy subjects and 10 patients). Bias and confidence intervals were obtained for end-systolic volume, end-diastolic volume and ejection fraction of 0.1 ± 3.5 mL, -0.6 ± 8.2 mL and -0.1 ± 2.2%, respectively.CONCLUSION: The proposed framework enables isotropic 3D Cartesian cardiac CINE under free breathing for fast assessment of cardiac anatomy and function.

KW - Adult

KW - Diastole/physiology

KW - Female

KW - Heart/diagnostic imaging

KW - Humans

KW - Imaging, Three-Dimensional

KW - Magnetic Resonance Imaging, Cine

KW - Male

KW - Middle Aged

KW - Motion

KW - Respiration

KW - Stroke Volume/physiology

KW - Systole/physiology

KW - Ventricular Function, Left/physiology

U2 - 10.1002/nbm.4409

DO - 10.1002/nbm.4409

M3 - Article

C2 - 32974984

SN - 0952-3480

VL - 34

SP - e4409

JO - NMR in Biomedicine

JF - NMR in Biomedicine

IS - 1

ER -